Organoidomics

Please contact Prof. Semin Lee, Jinho Jang or Web-master for any inquires.

3D Organoids

RAMP

Clinical Information

ID	Diagnosis	Stage	Age	BMI	Sex	CA19-9
P8	PDAC	3	68	15	Male	292.88

Mutation Profiles

Primary Tumor

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P8-Tissue	CLCNKA	1	16353849	C	T	Missense_Mutation	ENST00000439316.2:c.571C>T	ENSP00000414445.2:p.Arg234Trp	0.06726457
P8-Tissue	HECTD3	1	45472676	C	T	Missense_Mutation	ENST00000372172.4:c.1568G>A	ENSP00000361245.4:p.Arg523His	0.05860805
P8-Tissue	PBXIP1	1	154918357	TCC	AAG	Missense_Mutation	ENST00000542459.1:c.1326_1328delinsCTT	ENSP00000438584.1:p.Gln597_Glu598delinsHisLeu	0.00649350
P8-Tissue	PBXIP1	1	154918361	G	A	Nonsense_Mutation	ENST00000542459.1:c.1324C>T	ENSP00000438584.1:p.Gln597Ter	0.00636942
P8-Tissue	GBA	1	155207287	C	T	Missense_Mutation	ENST00000536770.1:c.505G>A	ENSP00000445560.1:p.Gly282Arg	0.04477611
P8-Tissue	CCDC181	1	169390821	G	T	Nonsense_Mutation	ENST00000545005.1:c.848C>A	ENSP00000442297.1:p.Ser283Ter	0.06493506
P8-Tissue	TNR	1	175365809	G	T	Missense_Mutation	ENST00000367674.2:c.1111C>A	ENSP00000356646.1:p.Gln371Lys	0.18115942
P8-Tissue	LYST	1	235884106	G	T	Missense_Mutation	ENST00000389794.3:c.9415C>A	ENSP00000374444.3:p.Gln3139Lys	0.08994709
P8-Tissue	TEKT4	2	95540690	C	T	Missense_Mutation	ENST00000295201.4:c.883C>T	ENSP00000295201.4:p.Arg295Cys	0.04090909
P8-Tissue	KCNH7	2	163228461	G	A	Missense_Mutation	ENST00000332142.5:c.3469C>T	ENSP00000331727.5:p.Arg1157Trp	0.05970149
P8-Tissue	GALNT3	2	166611543	C	A	Nonsense_Mutation	ENST00000409882.1:c.637G>T	ENSP00000386955.1:p.Glu213Ter	0.16666666
P8-Tissue	TTN	2	179396259	G	A	Missense_Mutation	ENST00000591111.1:c.100160C>T	ENSP00000465570.1:p.Thr33387Met	0.10091743
P8-Tissue	CCDC141	2	179732758	G	A	Missense_Mutation	ENST00000420890.2:c.2569C>T	ENSP00000395995.2:p.Arg857Trp	0.05109489
P8-Tissue	PTH1R	3	46944904	C	A	Missense_Mutation	ENST00000449590.1:c.1540C>A	ENSP00000402723.1:p.Leu514Ile	0.06338028
P8-Tissue	BSN	3	49690629	G	A	Missense_Mutation	ENST00000296452.4:c.3640G>A	ENSP00000296452.4:p.Gly1214Ser	0.08333333
P8-Tissue	HTR1F	3	88040765	G	A	Missense_Mutation	ENST00000319595.4:c.866G>A	ENSP00000322924.4:p.Arg289Gln	0.10062893
P8-Tissue	DLG1	3	196842906	G	C	Missense_Mutation	ENST00000452595.1:c.1086C>G	ENSP00000398939.1:p.Phe362Leu	0.04580152
P8-Tissue	FGG	4	155533284	C	A	Missense_Mutation	ENST00000407946.1:c.193G>T	ENSP00000384552.1:p.Asp65Tyr	0.06428571
P8-Tissue	PDZD2	5	31995725	C	T	Missense_Mutation	ENST00000438447.1:c.1022C>T	ENSP00000402033.1:p.Ser341Leu	0.09216589
P8-Tissue	DAB2	5	39382803	C	A	Missense_Mutation	ENST00000545653.1:c.1195G>T	ENSP00000439919.1:p.Val399Phe	0.10176991
P8-Tissue	CD14	5	140012123	A	C	Missense_Mutation	ENST00000401743.2:c.446T>G	ENSP00000385519.2:p.Leu149Arg	0.08247422
P8-Tissue	GABBR1	6	29595382	C	T	Missense_Mutation	ENST00000377034.4:c.538G>A	ENSP00000366233.4:p.Gly180Arg	0.09183673
P8-Tissue	HLA-DRB5	6	32487338	C	G	Missense_Mutation	ENST00000374975.3:c.461G>C	ENSP00000364114.3:p.Gly154Ala	0.04794520
P8-Tissue	HLA-DRB5	6	32487344	T	C	Missense_Mutation	ENST00000374975.3:c.455A>G	ENSP00000364114.3:p.Tyr152Cys	0.04861111
P8-Tissue	GLO1	6	38645160	CT	AG	Splice_Site	ENST00000373365.4:c.467-2_467-1inv		0.05813953
P8-Tissue	DAAM2	6	39867880	C	T	Missense_Mutation	ENST00000538976.1:c.2704C>T	ENSP00000437808.1:p.Arg902Trp	0.07931034
P8-Tissue	MTRF1L	6	153323607	TC	T	Frame_Shift_Del	ENST00000367233.5:c.213del	ENSP00000356202.5:p.Asn72ThrfsTer21	0.04838709
P8-Tissue	MTRF1L	6	153323609	A	G	Missense_Mutation	ENST00000367233.5:c.212T>C	ENSP00000356202.5:p.Leu71Pro	0.04761904
P8-Tissue	INTS1	7	1539635	C	T	Missense_Mutation	ENST00000404767.3:c.569G>A	ENSP00000385722.3:p.Arg190Gln	0.08015267
P8-Tissue	SLC4A2	7	150773113	G	A	Missense_Mutation	ENST00000485713.1:c.3485G>A	ENSP00000419412.1:p.Arg1162His	0.13888888
P8-Tissue	TNKS	8	9627661	G	T	Missense_Mutation	ENST00000518281.1:c.3075G>T	ENSP00000429890.1:p.Gln1025His	0.09523809
P8-Tissue	SLCO5A1	8	70585409	C	T	Missense_Mutation	ENST00000530307.1:c.2077G>A	ENSP00000431611.1:p.Val693Ile	0.07977208
P8-Tissue	RIMS2	8	105001597	C	T	Nonsense_Mutation	ENST00000507740.1:c.2368C>T	ENSP00000423559.1:p.Arg790Ter	0.18571428
P8-Tissue	CSMD3	8	113240986	T	A	Missense_Mutation	ENST00000455883.2:c.10456A>T	ENSP00000412263.2:p.Arg3486Trp	0.07407407
P8-Tissue	CSMD3	8	113303747	T	G	Missense_Mutation	ENST00000455883.2:c.8459A>C	ENSP00000412263.2:p.Glu2820Ala	0.07258064
P8-Tissue	COL15A1	9	101767303	G	A	Missense_Mutation	ENST00000375001.3:c.1324G>A	ENSP00000364140.3:p.Ala442Thr	0.05325443
P8-Tissue	BSPRY	9	116122925	C	T	Missense_Mutation	ENST00000374183.4:c.439C>T	ENSP00000363298.4:p.Arg147Trp	0.08745247
P8-Tissue	ABCA2	9	139902941	C	A	Missense_Mutation	ENST00000371605.3:c.7199G>T	ENSP00000360666.3:p.Arg2400Leu	0.04455445
P8-Tissue	ZNF33A	10	38343552	C	A	Missense_Mutation	ENST00000458705.2:c.497C>A	ENSP00000387713.2:p.Ser166Tyr	0.09259259
P8-Tissue	IFITM3	11	320606	G	T	Missense_Mutation	ENST00000602735.1:c.145C>A	ENSP00000473544.1:p.Pro49Thr	0.08923884
P8-Tissue	CCDC87	11	66358943	A	G	Missense_Mutation	ENST00000333861.3:c.1544T>C	ENSP00000328487.3:p.Val515Ala	0.08982035
P8-Tissue	CACNA1C	12	2676932	C	T	Missense_Mutation	ENST00000480911.1:c.1867C>T	ENSP00000437936.1:p.Arg623Trp	0.11304347
P8-Tissue	KIAA1467	12	13208617	C	T	Missense_Mutation	ENST00000197268.8:c.170C>T	ENSP00000197268.8:p.Ala57Val	0.05325443
P8-Tissue	KRAS	12	25398284	C	A	Missense_Mutation	ENST00000557334.1:c.35G>T	ENSP00000452512.1:p.Gly12Val	0.05696202
P8-Tissue	TDG	12	104359839	G	C	Splice_Site	ENST00000544861.1:c.-264+1G>C		0.016
P8-Tissue	MYH7	14	23887458	G	A	Missense_Mutation	ENST00000355349.3:c.4130C>T	ENSP00000347507.3:p.Thr1377Met	0.06030150
P8-Tissue	REC8	14	24642136	C	T	Nonsense_Mutation	ENST00000559919.1:c.154C>T	ENSP00000453242.1:p.Arg52Ter	0.08778626
P8-Tissue	ALPK3	15	85400031	G	A	Missense_Mutation	ENST00000258888.5:c.2668G>A	ENSP00000258888.5:p.Ala890Thr	0.04761904
P8-Tissue	ADCY9	16	4016815	T	A	Missense_Mutation	ENST00000294016.3:c.3023A>T	ENSP00000294016.3:p.Tyr1008Phe	0.00588235
P8-Tissue	MMP15	16	58077528	G	A	Missense_Mutation	ENST00000219271.3:c.1567G>A	ENSP00000219271.3:p.Ala523Thr	0.04575163
P8-Tissue	TBC1D29	17	28890280	C	T	Missense_Mutation	ENST00000584297.1:c.241C>T	ENSP00000463703.1:p.Arg81Cys	0.07443365
P8-Tissue	TTYH2	17	72227032	C	T	Missense_Mutation	ENST00000529107.1:c.245C>T	ENSP00000433089.1:p.Ala82Val	0.11627907
P8-Tissue	MYO9B	19	17317947	C	A	Missense_Mutation	ENST00000595618.1:c.5518C>A	ENSP00000471457.1:p.Arg1840Ser	0.09287925
P8-Tissue	FKRP	19	47259843	G	A	Missense_Mutation	ENST00000391909.3:c.1136G>A	ENSP00000375776.2:p.Arg379Gln	0.0625
P8-Tissue	LILRA1	19	55106288	A	C	Missense_Mutation	ENST00000453777.1:c.229A>C	ENSP00000413715.1:p.Ile77Leu	0.15533980
P8-Tissue	KRTAP13-3	21	31798010	C	A	Missense_Mutation	ENST00000390690.2:c.221G>T	ENSP00000375109.2:p.Ser74Ile	0.14285714
P8-Tissue	CLDN5	22	19511457	C	T	Missense_Mutation	ENST00000413119.2:c.577G>A	ENSP00000400612.2:p.Val193Met	0.18279569
P8-Tissue	COMT	22	19950200	A	C	Translation_Start_Site	ENST00000449653.1:c.1A>C	ENSP00000416778.1:p.Met1?	0.00689655
P8-Tissue	COMT	22	19950202	G	T	Translation_Start_Site	ENST00000449653.1:c.3G>T	ENSP00000416778.1:p.Met1?	0.00680272
P8-Tissue	RFPL1	22	29837827	A	G	Missense_Mutation	ENST00000354373.2:c.670A>G	ENSP00000346342.2:p.Ser224Gly	0.05698005
P8-Tissue	ITIH6	X	54784573	A	G	Missense_Mutation	ENST00000218436.6:c.1934T>C	ENSP00000218436.6:p.Val645Ala	0.16470588
P8-Tissue	ERCC6L	X	71426903	G	C	Missense_Mutation	ENST00000373657.1:c.1345C>G	ENSP00000362761.1:p.Arg449Gly	0.07692307
P8-Tissue	BRCC3	X	154305514	C	T	Nonsense_Mutation	ENST00000399042.1:c.265C>T	ENSP00000381998.1:p.Arg89Ter	0.09859154

Organoid

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P8-Organoid	PER3	1	7887343	C	A	Missense_Mutation	ENST00000377532.3:c.2354C>A	ENSP00000366755.3:NA	0.05633802
P8-Organoid	HECTD3	1	45472676	C	T	Missense_Mutation	ENST00000372172.4:c.1568G>A	ENSP00000361245.4:p.Arg523His	0.41032608
P8-Organoid	NASP	1	46073697	C	A	Missense_Mutation	ENST00000537798.1:c.922C>A	ENSP00000438871.1:NA	0.12574850
P8-Organoid	FLG	1	152281783	C	A	Missense_Mutation	ENST00000368799.1:c.5579G>T	ENSP00000357789.1:NA	0.40066225
P8-Organoid	GBA	1	155207287	C	T	Missense_Mutation	ENST00000536770.1:c.505G>A	ENSP00000445560.1:p.Gly282Arg	0.63448275
P8-Organoid	CCDC181	1	169390821	G	T	Nonsense_Mutation	ENST00000545005.1:c.848C>A	ENSP00000442297.1:p.Ser283Ter	0.50241545
P8-Organoid	HMCN1	1	186099193	G	A	Missense_Mutation	ENST00000367492.2:c.13000G>A	ENSP00000356462.2:p.Val4334Ile	0.50337837
P8-Organoid	HEATR1	1	236746489	G	T	Missense_Mutation	ENST00000366582.3:c.2249C>A	ENSP00000355541.3:p.Pro750His	0.05
P8-Organoid	GALNT14	2	31154986	G	A	Missense_Mutation	ENST00000420311.2:c.901C>T	ENSP00000415514.2:p.Arg301Trp	0.43157894
P8-Organoid	TEKT4	2	95540690	C	T	Missense_Mutation	ENST00000295201.4:c.883C>T	ENSP00000295201.4:p.Arg295Cys	0.53418803
P8-Organoid	KCNH7	2	163228461	G	A	Missense_Mutation	ENST00000332142.5:c.3469C>T	ENSP00000331727.5:p.Arg1157Trp	0.55905511
P8-Organoid	GALNT3	2	166611543	C	A	Nonsense_Mutation	ENST00000409882.1:c.637G>T	ENSP00000386955.1:p.Glu213Ter	0.42105263
P8-Organoid	TTN	2	179396259	G	A	Missense_Mutation	ENST00000591111.1:c.100160C>T	ENSP00000465570.1:p.Thr33387Met	0.57281553
P8-Organoid	CCDC141	2	179732758	G	A	Missense_Mutation	ENST00000420890.2:c.2569C>T	ENSP00000395995.2:p.Arg857Trp	0.47894736
P8-Organoid	PTH1R	3	46944904	C	A	Missense_Mutation	ENST00000449590.1:c.1540C>A	ENSP00000402723.1:p.Leu514Ile	0.36893203
P8-Organoid	BSN	3	49690629	G	A	Missense_Mutation	ENST00000296452.4:c.3640G>A	ENSP00000296452.4:p.Gly1214Ser	0.26436781
P8-Organoid	HTR1F	3	88040765	G	A	Missense_Mutation	ENST00000319595.4:c.866G>A	ENSP00000322924.4:p.Arg289Gln	0.33179723
P8-Organoid	DLG1	3	196842906	G	C	Missense_Mutation	ENST00000452595.1:c.1086C>G	ENSP00000398939.1:p.Phe362Leu	0.48255814
P8-Organoid	EPHA5	4	66535297	G	T	Missense_Mutation	ENST00000511294.1:c.164C>A	ENSP00000427638.1:p.Ala55Asp	0.49163879
P8-Organoid	FGG	4	155533284	C	A	Missense_Mutation	ENST00000407946.1:c.193G>T	ENSP00000384552.1:p.Asp65Tyr	0.43076923
P8-Organoid	FRG1	4	190878562	G	C	Missense_Mutation	ENST00000226798.4:c.442G>C	ENSP00000226798.4:p.Ala148Pro	0.06785714
P8-Organoid	DNAH5	5	13841872	G	A	Missense_Mutation	ENST00000265104.4:c.5413C>T	ENSP00000265104.4:p.Arg1805Cys	0.41637010
P8-Organoid	PDZD2	5	31995725	C	T	Missense_Mutation	ENST00000438447.1:c.1022C>T	ENSP00000402033.1:p.Ser341Leu	0.58122743
P8-Organoid	RASA1	5	86675600	A	G	Missense_Mutation	ENST00000512763.1:c.2035A>G	ENSP00000422008.1:p.Thr679Ala	0.01886792
P8-Organoid	RASA1	5	86675613	A	G	Missense_Mutation	ENST00000512763.1:c.2048A>G	ENSP00000422008.1:p.Asn683Ser	0.01877934
P8-Organoid	FBN2	5	127800456	G	A	Missense_Mutation	ENST00000508989.1:c.688C>T	ENSP00000425596.1:p.Arg230Trp	0.42950819
P8-Organoid	CD14	5	140012123	A	C	Missense_Mutation	ENST00000401743.2:c.446T>G	ENSP00000385519.2:p.Leu149Arg	0.43298969
P8-Organoid	FAT2	5	150945519	G	A	Nonsense_Mutation	ENST00000261800.5:c.2974C>T	ENSP00000261800.5:p.Arg992Ter	0.42971887
P8-Organoid	GRK6	5	176863097	C	T	Missense_Mutation	ENST00000528793.1:c.1081C>T	ENSP00000433511.1:p.Arg361Trp	0.01302931
P8-Organoid	TXNDC5	6	7889768	C	A	Missense_Mutation	ENST00000539054.1:c.563G>T	ENSP00000442453.1:p.Arg188Leu	0.052
P8-Organoid	DEF6	6	35278368	C	A	Missense_Mutation	ENST00000316637.5:c.370C>A	ENSP00000319831.5:p.Leu124Ile	0.02439024
P8-Organoid	DAAM2	6	39867880	C	T	Missense_Mutation	ENST00000538976.1:c.2704C>T	ENSP00000437808.1:p.Arg902Trp	0.47784810
P8-Organoid	B3GAT2	6	71603915	C	T	Missense_Mutation	ENST00000230053.6:c.652G>A	ENSP00000230053.6:p.Glu218Lys	0.53125
P8-Organoid	RIMS1	6	72809681	G	A	Missense_Mutation	ENST00000522291.1:c.463G>A	ENSP00000430932.1:p.Asp155Asn	0.43506493
P8-Organoid	MTRF1L	6	153323607	TC	T	Frame_Shift_Del	ENST00000367233.5:c.213del	ENSP00000356202.5:p.Asn72ThrfsTer21	0.24
P8-Organoid	MTRF1L	6	153323609	A	G	Missense_Mutation	ENST00000367233.5:c.212T>C	ENSP00000356202.5:p.Leu71Pro	0.25630252
P8-Organoid	INTS1	7	1539635	C	T	Missense_Mutation	ENST00000404767.3:c.569G>A	ENSP00000385722.3:p.Arg190Gln	0.55095541
P8-Organoid	SAMD9	7	92734512	GAT	G	Frame_Shift_Del	ENST00000379958.2:c.897_898del	ENSP00000369292.2:p.Ser300Ter	0.27665706
P8-Organoid	CCDC132	7	92935261	A	C	Missense_Mutation	ENST00000544910.1:c.1484A>C	ENSP00000443104.1:p.Glu495Ala	0.04246284
P8-Organoid	SLC4A2	7	150773113	G	A	Missense_Mutation	ENST00000485713.1:c.3485G>A	ENSP00000419412.1:p.Arg1162His	0.68796068
P8-Organoid	TNKS	8	9627661	G	T	Missense_Mutation	ENST00000518281.1:c.3075G>T	ENSP00000429890.1:p.Gln1025His	0.41422594
P8-Organoid	LOXL2	8	23198632	C	T	Missense_Mutation	ENST00000389131.3:c.616G>A	ENSP00000373783.3:p.Val206Met	0.50961538
P8-Organoid	NRG1	8	31498025	G	C	Missense_Mutation	ENST00000520407.1:c.525G>C	ENSP00000434640.1:p.Leu175Phe	0.52586206
P8-Organoid	SLCO5A1	8	70585409	C	T	Missense_Mutation	ENST00000530307.1:c.2077G>A	ENSP00000431611.1:p.Val693Ile	0.48155339
P8-Organoid	RIMS2	8	105001597	C	T	Nonsense_Mutation	ENST00000507740.1:c.2368C>T	ENSP00000423559.1:p.Arg790Ter	0.46153846
P8-Organoid	CSMD3	8	113303747	T	G	Missense_Mutation	ENST00000455883.2:c.8459A>C	ENSP00000412263.2:p.Glu2820Ala	0.50282485
P8-Organoid	GLDC	9	6645348	C	T	Missense_Mutation	ENST00000321612.6:c.152G>A	ENSP00000370737.3:p.Arg51His	0.52238806
P8-Organoid	VPS13A	9	79938064	C	A	Missense_Mutation	ENST00000376636.3:c.5795C>A	ENSP00000365823.3:p.Ser1932Tyr	0.01538461
P8-Organoid	COL15A1	9	101767303	G	A	Missense_Mutation	ENST00000375001.3:c.1324G>A	ENSP00000364140.3:p.Ala442Thr	0.47852760
P8-Organoid	SEC16A	9	139370593	AG	A	Frame_Shift_Del	ENST00000431893.2:c.940del	ENSP00000387583.2:p.Leu314PhefsTer80	0.33962264
P8-Organoid	ABCA2	9	139902941	C	A	Missense_Mutation	ENST00000371605.3:c.7199G>T	ENSP00000360666.3:p.Arg2400Leu	0.43352601
P8-Organoid	ZNF33A	10	38343552	C	A	Missense_Mutation	ENST00000458705.2:c.497C>A	ENSP00000387713.2:p.Ser166Tyr	0.42056074
P8-Organoid	COMTD1	10	76995486	G	T	Missense_Mutation	ENST00000372538.3:c.110C>A	ENSP00000361616.3:p.Pro37Gln	0.03053435
P8-Organoid	IFITM3	11	320606	G	T	Missense_Mutation	ENST00000602735.1:c.145C>A	ENSP00000473544.1:p.Pro49Thr	0.17241379
P8-Organoid	OR51E1	11	4674660	C	T	Nonsense_Mutation	ENST00000396952.5:c.904C>T	ENSP00000380155.5:p.Arg302Ter	0.22222222
P8-Organoid	OR8K5	11	55927102	G	A	Missense_Mutation	ENST00000313447.1:c.692C>T	ENSP00000323853.1:p.Ala231Val	0.08888888
P8-Organoid	CCDC87	11	66358943	A	G	Missense_Mutation	ENST00000333861.3:c.1544T>C	ENSP00000328487.3:p.Val515Ala	0.45323741
P8-Organoid	CABP2	11	67290114	C	A	Missense_Mutation	ENST00000294288.4:c.116G>T	ENSP00000294288.4:p.Gly39Val	0.03067484
P8-Organoid	POLD3	11	74345691	C	T	Missense_Mutation	ENST00000532497.1:c.752C>T	ENSP00000436018.1:p.Pro251Leu	0.4625
P8-Organoid	FAM181B	11	82443985	CC	GA	Missense_Mutation	ENST00000329203.3:c.786_787delinsTC	ENSP00000365295.2:p.Glu263Gln	0.07142857
P8-Organoid	DLG2	11	83180399	G	A	Nonsense_Mutation	ENST00000543673.1:c.2464C>T	ENSP00000441994.1:p.Arg822Ter	0.37857142
P8-Organoid	CACNA1C	12	2676932	C	T	Missense_Mutation	ENST00000480911.1:c.1867C>T	ENSP00000437936.1:p.Arg623Trp	0.51470588
P8-Organoid	KIAA1467	12	13208617	C	T	Missense_Mutation	ENST00000197268.8:c.170C>T	ENSP00000197268.8:p.Ala57Val	0.41578947
P8-Organoid	KRAS	12	25398284	C	A	Missense_Mutation	ENST00000557334.1:c.35G>T	ENSP00000452512.1:p.Gly12Val	0.41991342
P8-Organoid	YARS2	12	32908360	G	T	Missense_Mutation	ENST00000324868.8:c.449C>A	ENSP00000320658.8:p.Ala150Asp	0.01185770
P8-Organoid	NCKAP5L	12	50189475	C	A	Missense_Mutation	ENST00000335999.6:c.2168G>T	ENSP00000337998.6:p.Gly723Val	0.04651162
P8-Organoid	KRT18	12	53344140	G	A	Missense_Mutation	ENST00000550600.1:c.446G>A	ENSP00000447278.1:p.Arg149His	0.02702702
P8-Organoid	TMEM132D	12	130185148	A	G	Missense_Mutation	ENST00000422113.2:c.175T>C	ENSP00000408581.2:p.Ser59Pro	0.02013422
P8-Organoid	MYH7	14	23887458	G	A	Missense_Mutation	ENST00000355349.3:c.4130C>T	ENSP00000347507.3:p.Thr1377Met	0.51555555
P8-Organoid	DHRS4	14	24435037	C	T	Nonsense_Mutation	ENST00000559632.1:c.373C>T	ENSP00000453983.1:p.Arg125Ter	0.1796875
P8-Organoid	REC8	14	24642136	C	T	Nonsense_Mutation	ENST00000559919.1:c.154C>T	ENSP00000453242.1:p.Arg52Ter	0.5
P8-Organoid	NOVA1	14	27066585	G	T	Missense_Mutation	ENST00000574031.1:c.58C>A	ENSP00000459545.1:p.Leu20Met	0.48275862
P8-Organoid	RP11-176H8.1	14	31926584	G	A	Missense_Mutation	ENST00000547378.1:c.16C>T	ENSP00000447056.1:p.Arg6Trp	0.16778523
P8-Organoid	HERC2	15	28447727	CAGCCAAGCACTGGCA	C	In_Frame_Del	ENST00000261609.7:c.7231_7245del	ENSP00000261609.7:p.Cys2411_Ala2415del	0.00512820
P8-Organoid	PARP6	15	72559151	G	T	Missense_Mutation	ENST00000569795.1:c.16C>A	ENSP00000456348.1:p.Gln6Lys	0.03731343
P8-Organoid	SIN3A	15	75715041	G	A	Missense_Mutation	ENST00000567289.1:c.313C>T	ENSP00000455834.1:p.Pro105Ser	0.46919431
P8-Organoid	MSLNL	16	825559	GC	TT	Missense_Mutation	ENST00000293892.3:c.1201_1202delinsAA	ENSP00000293892.3:p.Ala401Lys	0.09523809
P8-Organoid	SALL1	16	51175481	C	T	Missense_Mutation	ENST00000440970.1:c.361G>A	ENSP00000407914.1:p.Gly121Arg	0.47651006
P8-Organoid	MMP15	16	58077528	G	A	Missense_Mutation	ENST00000219271.3:c.1567G>A	ENSP00000219271.3:p.Ala523Thr	0.55140186
P8-Organoid	TBC1D29	17	28890280	C	T	Missense_Mutation	ENST00000584297.1:c.241C>T	ENSP00000463703.1:p.Arg81Cys	0.42774566
P8-Organoid	TTYH2	17	72227032	C	T	Missense_Mutation	ENST00000529107.1:c.245C>T	ENSP00000433089.1:p.Ala82Val	0.56666666
P8-Organoid	SMAD4	18	48591855	A	G	Missense_Mutation	ENST00000588745.1:c.730A>G	ENSP00000464901.1:p.Lys244Glu	0.99074074
P8-Organoid	FKRP	19	47259843	G	A	Missense_Mutation	ENST00000391909.3:c.1136G>A	ENSP00000375776.2:p.Arg379Gln	0.63449692
P8-Organoid	CACNG8	19	54485586	G	T	Missense_Mutation	ENST00000270458.2:c.761G>T	ENSP00000270458.2:p.Gly254Val	0.03680981
P8-Organoid	KRTAP13-3	21	31798010	C	A	Missense_Mutation	ENST00000390690.2:c.221G>T	ENSP00000375109.2:p.Ser74Ile	0.66917293
P8-Organoid	CLDN5	22	19511457	C	T	Missense_Mutation	ENST00000413119.2:c.577G>A	ENSP00000400612.2:p.Val193Met	1
P8-Organoid	SMC1B	22	45750900	TG	T	Frame_Shift_Del	ENST00000404354.3:c.3056del	ENSP00000385902.3:p.Pro1019GlnfsTer9	0.94736842
P8-Organoid	ITIH6	X	54784573	A	G	Missense_Mutation	ENST00000218436.6:c.1934T>C	ENSP00000218436.6:p.Val645Ala	1
P8-Organoid	ERCC6L	X	71426903	G	C	Missense_Mutation	ENST00000373657.1:c.1345C>G	ENSP00000362761.1:p.Arg449Gly	0.97938144
P8-Organoid	ATRX	X	76777835	C	A	Missense_Mutation	ENST00000395603.3:c.6767G>T	ENSP00000378967.3:p.Gly2256Val	0.02631578
P8-Organoid	BRCC3	X	154305514	C	T	Nonsense_Mutation	ENST00000399042.1:c.265C>T	ENSP00000381998.1:p.Arg89Ter	1

Somatic Copy Number Alterations

Primary Tumor

Organoid

Concordance between Primary tumor and Organoid

VAF-VAF Plot

Number of Shared Mutations between Primary tumor and organoid (All mutations)

Number of Shared Mutations between Primary tumor and organoid (Functional mutations)

Drug Responses

ID	Drug	IC50
P8	AZD2014	~ 45088820
P8	AZD3759	~ 2.073e-007
P8	AZD4547	~ 4996374013
P8	AZD5363	413.9
P8	AZD6738	2730
P8	AZD9291	2077
P8	I.BET.762	498.8
P8	Rapamycin..Sirolimus.	~ 90915439
P8	AZD1775..MK.1775.	299.3
P8	Triptolide..PG490.	39.67
P8	Simvastatin	96.09
P8	Temozolomide	1.69E+56
P8	Imatinib.Mesylate..STI571.	~ 2163137
P8	Pazopanib..GW786034.	~ 587692
P8	Sunitinib.Malate	2456
P8	Olaparib..AZD2281..KU0059436.	14575
P8	Regorafenib..BAY.73.4506.	2057
P8	Erlotinib	1205
P8	Gefitinib	~ 1.237e+031
P8	Afatinib	1746
P8	OTX.015	190.6
P8	BKM120..NVP.BKM120.	1484
P8	BYL719	~ 21020
P8	Cediranib..AZD2171.	3268
P8	Ceritinib.LDK378.	952.5
P8	Crizotinib...PF.02341066.	4922
P8	Dabrafenib	4902
P8	Dacomitinib	305.5
P8	Everolimus..RAD001.	~ 0.000
P8	Ibrutinib..PCI.32765.	11003
P8	Lapatinib	~ 5064
P8	LY2835219	438.6
P8	Brivanib..BMS.582664.	~ 20683
P8	Panobinostat	31.53
P8	Selumetinib..AZD6244.	3100
P8	Sorafenib	~ 5721
P8	Trametinib	519.6
P8	Vandetanib..ZD6474.	~ 1258
P8	Vemurafenib	3.80455E+11
P8	AZD5153	32.48
P8	ABT.199..GDC.0199..	~ 46265439274194
P8	ABT.888..Veliparib..NSC.737664.	~ 289484782983
P8	Avagacestat..BMS.708163.	1.316E+42
P8	Axitinib...AG.013736.	1081
P8	Bosutinib..SKI.606.	3125
P8	Cabozantinib..XL184.	~ 1.265e+031
P8	Dasatinib..BMS.354825.	15884
P8	decitabine	~ 2.967e+033
P8	defactinib	1269
P8	Dovitinib..TKI258.CHIR258.	807.7
P8	Fluorouracil..5.Fluoracil..5.FU.	4561
P8	Foretinib..XL880.	~ 47101787914
P8	Tivantinib..ARQ.197.	183.9
P8	Abraxane	97.19
P8	AZD2461.olaparib.analog.	0.05244
P8	Olaparib.	~ 299.8
P8	Idelalisib	~ 186.1
P8	Irinotecan	340.3
P8	Nilotinib..AMN.107.	~ 1261
P8	NVP.AEW541	~ 2.319e+017
P8	Oxaliplatin	~ 21.87
P8	PLX3397	4049
P8	Quizartinib..AC220.	8876
P8	Saracatinib..AZD0530.	~ 6069
P8	Semagacestat..LY450139.	~ 26631
P8	TGX.221	8244
P8	tozasertib	62.78
P8	Vorinostat..SAHA..MK0683.	3893
P8	XAV939	~ 1.409e-006
P8	gemcitabine	3845
P8	palbociclib	12242
P8	Neratinib..HKI.272.	24.51