Organoidomics

Please contact Prof. Semin Lee, Jinho Jang or Web-master for any inquires.

3D Organoids

RAMP

Clinical Information

ID	Diagnosis	Stage	Age	BMI	Sex	CA19-9
P7	PDAC (known Bladder cancer as well 2019.7.26 TURB, papillary urotherlial ca grade I/III without stromal invasion)	3	78	20.7	Male	7.29

Mutation Profiles

Primary Tumor

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P7-Tissue	ARHGEF16	1	3397129	T	A	Missense_Mutation	ENST00000413250.2:c.1220T>A	ENSP00000408887.2:p.Leu703Gln	0.21839080
P7-Tissue	RNF207	1	6278414	A	G	Missense_Mutation	ENST00000377939.4:c.1718A>G	ENSP00000367173.4:p.Asn573Ser	0.11764705
P7-Tissue	MACF1	1	39927704	G	A	Missense_Mutation	ENST00000567887.1:c.21784G>A	ENSP00000455823.1:p.Asp5166Asn	0.18181818
P7-Tissue	SRSF11	1	70710400	T	A	Missense_Mutation	ENST00000405432.1:c.834T>A	ENSP00000384357.1:p.His278Gln	0.12244898
P7-Tissue	SLC6A17	1	110740758	G	A	Missense_Mutation	ENST00000331565.4:c.1876G>A	ENSP00000330199.3:p.Val626Ile	0.18439716
P7-Tissue	FAM212B	1	112269922	G	A	Missense_Mutation	ENST00000444059.2:c.517C>T	ENSP00000408238.2:p.Arg173Cys	0.19875776
P7-Tissue	CACNA1E	1	181762828	G	A	Missense_Mutation	ENST00000367573.2:c.5926G>A	ENSP00000356545.2:p.Val1976Met	0.15962441
P7-Tissue	CDC73	1	193107258	G	A	Missense_Mutation	ENST00000367435.3:c.467G>A	ENSP00000356405.3:p.Arg156His	0.21052631
P7-Tissue	PPP1R15B	1	204380425	G	A	Missense_Mutation	ENST00000367188.4:c.115C>T	ENSP00000356156.4:p.Pro39Ser	0.14210526
P7-Tissue	CENPF	1	214815344	A	T	Missense_Mutation	ENST00000366955.3:c.3663A>T	ENSP00000355922.3:p.Glu1221Asp	0.15652173
P7-Tissue	LIN9	1	226420285	T	C	Missense_Mutation	ENST00000366801.1:c.1441A>G	ENSP00000355766.1:p.Ile481Val	0.17647058
P7-Tissue	PRSS38	1	228033727	C	T	Nonsense_Mutation	ENST00000366757.3:c.799C>T	ENSP00000355719.3:p.Arg267Ter	0.16129032
P7-Tissue	THADA	2	43735806	C	T	Missense_Mutation	ENST00000415080.2:c.2618G>A	ENSP00000416048.2:p.Gly873Glu	0.23255814
P7-Tissue	FIGN	2	164467236	G	A	Missense_Mutation	ENST00000333129.3:c.1106C>T	ENSP00000333836.3:p.Ala369Val	0.15517241
P7-Tissue	LRP2	2	170063415	C	T	Missense_Mutation	ENST00000263816.3:c.6815G>A	ENSP00000263816.3:p.Arg2272His	0.15384615
P7-Tissue	SMARCAL1	2	217315759	C	T	Missense_Mutation	ENST00000358207.5:c.2042C>T	ENSP00000350940.5:p.Ala681Val	0.18548387
P7-Tissue	FBLN2	3	13612273	G	A	Missense_Mutation	ENST00000535798.1:c.496G>A	ENSP00000445705.1:p.Val166Ile	0.16315789
P7-Tissue	TTC29	4	147830322	C	T	Missense_Mutation	ENST00000513335.1:c.334G>A	ENSP00000423505.1:p.Ala112Thr	0.19186046
P7-Tissue	C5orf42	5	37177754	T	A	Missense_Mutation	ENST00000508244.1:c.5869A>T	ENSP00000421690.1:p.Ile1957Phe	0.08955223
P7-Tissue	FAT2	5	150928895	G	A	Missense_Mutation	ENST00000261800.5:c.4750C>T	ENSP00000261800.5:p.Arg1584Trp	0.14406779
P7-Tissue	CCNG1	5	162866441	TTAGTC	T	Frame_Shift_Del	ENST00000393929.1:c.182_186del	ENSP00000377506.1:p.Ser61AsnfsTer7	0.11016949
P7-Tissue	RREB1	6	7229596	G	A	Missense_Mutation	ENST00000379938.2:c.1264G>A	ENSP00000369270.2:p.Gly422Ser	0.19383259
P7-Tissue	PHF1	6	33382896	G	A	Missense_Mutation	ENST00000374516.3:c.1214G>A	ENSP00000363640.3:p.Arg405Gln	0.11111111
P7-Tissue	EYS	6	66204694	G	T	Missense_Mutation	ENST00000503581.1:c.610C>A	ENSP00000424243.1:p.Pro204Thr	0.17535545
P7-Tissue	GLI3	7	42004454	G	A	Missense_Mutation	ENST00000395925.3:c.4217C>T	ENSP00000379258.3:p.Ser1406Leu	0.23699422
P7-Tissue	ADCY1	7	45632476	G	A	Missense_Mutation	ENST00000432715.1:c.83G>A	ENSP00000392721.1:p.Arg28Gln	0.17289719
P7-Tissue	SEMA3E	7	83029503	G	A	Nonsense_Mutation	ENST00000427262.1:c.1027C>T	ENSP00000405052.1:p.Arg343Ter	0.07272727
P7-Tissue	TFR2	7	100238772	T	A	Missense_Mutation	ENST00000462107.1:c.113A>T	ENSP00000420525.1:p.Glu38Val	0.02797202
P7-Tissue	CAV1	7	116199043	G	A	Missense_Mutation	ENST00000405348.1:c.146G>A	ENSP00000384348.1:p.Ser49Asn	0.12626262
P7-Tissue	UNC5D	8	35579823	C	T	Missense_Mutation	ENST00000453357.2:c.1198C>T	ENSP00000394303.2:p.Arg400Trp	0.09146341
P7-Tissue	PTPRD	9	8484207	G	A	Missense_Mutation	ENST00000540109.1:c.3325C>T	ENSP00000438164.1:p.Arg1109Cys	0.14864864
P7-Tissue	REXO4	9	136272156	A	C	Missense_Mutation	ENST00000371942.3:c.1190T>G	ENSP00000361010.3:p.Val397Gly	0.19607843
P7-Tissue	FBXW5	9	139836056	C	T	Missense_Mutation	ENST00000325285.3:c.1177G>A	ENSP00000313034.3:p.Asp393Asn	0.16379310
P7-Tissue	IL2RA	10	6063525	C	T	Missense_Mutation	ENST00000379959.3:c.499G>A	ENSP00000369293.3:p.Val167Ile	0.17714285
P7-Tissue	ARHGAP21	10	24874912	C	CAT	Frame_Shift_Ins	ENST00000396432.2:c.4304_4305dup	ENSP00000379709.2:p.Glu1436MetfsTer59	0.17105263
P7-Tissue	PCDH15	10	56138588	T	A	Missense_Mutation	ENST00000437009.1:c.272A>T	ENSP00000412628.1:p.Lys91Met	0.22330097
P7-Tissue	JMJD1C	10	64968832	T	A	Missense_Mutation	ENST00000542921.1:c.2312A>T	ENSP00000444682.1:p.His771Leu	0.18181818
P7-Tissue	MAT1A	10	82034849	C	T	Missense_Mutation	ENST00000372213.3:c.875G>A	ENSP00000361287.3:p.Arg292His	0.1
P7-Tissue	SLIT1	10	98945427	G	A	Missense_Mutation	ENST00000371070.4:c.5C>T	ENSP00000360109.4:p.Ala2Val	0.10891089
P7-Tissue	PKD2L1	10	102089791	C	T	Missense_Mutation	ENST00000353274.3:c.70G>A	ENSP00000266049.6:p.Ala24Thr	0.15853658
P7-Tissue	TLX1	10	102896638	AGCGTCAC	A	Frame_Shift_Del	ENST00000370196.6:c.963_969del	ENSP00000359215.6:p.Val322ArgfsTer88	0.15384615
P7-Tissue	INPP5F	10	121551117	C	T	Missense_Mutation	ENST00000369083.3:c.404C>T	ENSP00000358079.3:p.Thr135Met	0.12121212
P7-Tissue	ATF7IP	12	14631397	C	A	Missense_Mutation	ENST00000544627.1:c.3112C>A	ENSP00000440440.1:p.Leu1038Ile	0.20202020
P7-Tissue	KRAS	12	25398284	C	A	Missense_Mutation	ENST00000557334.1:c.35G>T	ENSP00000452512.1:p.Gly12Val	0.18333333
P7-Tissue	PDZRN4	12	41582415	C	T	Missense_Mutation	ENST00000402685.2:c.158C>T	ENSP00000384197.2:p.Pro53Leu	0.16216216
P7-Tissue	PRPF40B	12	50036068	A	ACTGC	Frame_Shift_Ins	ENST00000548825.2:c.1936_1937insTGCC	ENSP00000448073.2:p.Arg646LeufsTer33	0.08571428
P7-Tissue	IRAK3	12	66638283	A	G	Missense_Mutation	ENST00000457197.2:c.722A>G	ENSP00000409852.2:p.Asp241Gly	0.13829787
P7-Tissue	ATP2B1	12	90029030	T	G	Splice_Site	ENST00000428670.3:c.407-2A>C		0.10476190
P7-Tissue	SMAD9	13	37422869	C	T	Missense_Mutation	ENST00000399275.2:c.1348G>A	ENSP00000382216.2:p.Asp450Asn	0.20238095
P7-Tissue	ACIN1	14	23559749	C	T	Missense_Mutation	ENST00000605057.1:c.298G>A	ENSP00000474349.1:p.Glu100Lys	0.13095238
P7-Tissue	FAM63B	15	59146700	C	T	Missense_Mutation	ENST00000559228.1:c.1757C>T	ENSP00000452885.1:p.Ala586Val	0.17808219
P7-Tissue	WFIKKN1	16	683672	G	A	Missense_Mutation	ENST00000319070.2:c.1262G>A	ENSP00000324763.2:p.Arg421His	0.16233766
P7-Tissue	C16orf62	16	19613027	A	T	Missense_Mutation	ENST00000543152.1:c.13A>T	ENSP00000457973.1:p.Ser5Cys	0.125
P7-Tissue	CD19	16	28947894	T	G	Missense_Mutation	ENST00000567541.1:c.1057T>G	ENSP00000456201.1:p.Ser353Ala	0.13913043
P7-Tissue	DLX3	17	48070774	G	A	Missense_Mutation	ENST00000512495.2:c.146C>T	ENSP00000449976.1:p.Thr49Met	0.08547008
P7-Tissue	SALL3	18	76752427	C	T	Missense_Mutation	ENST00000575389.2:c.436C>T	ENSP00000458360.2:p.Arg146Trp	0.21052631
P7-Tissue	PTPRS	19	5238990	G	A	Missense_Mutation	ENST00000592099.1:c.1750C>T	ENSP00000467398.1:p.Arg584Cys	0.05527638
P7-Tissue	C19orf18	19	58485469	G	A	Missense_Mutation	ENST00000314391.3:c.224C>T	ENSP00000321519.2:p.Thr75Met	0.11111111
P7-Tissue	TGM6	20	2378669	G	A	Missense_Mutation	ENST00000381423.1:c.649G>A	ENSP00000370831.1:p.Val217Ile	0.15789473
P7-Tissue	CST1	20	23729736	C	T	Missense_Mutation	ENST00000398402.1:c.259G>A	ENSP00000381439.1:p.Val87Ile	0.15355805
P7-Tissue	GNAS	20	57484420	C	T	Missense_Mutation	ENST00000371102.4:c.2488C>T	ENSP00000360143.4:p.Arg830Cys	0.19069767
P7-Tissue	KCNQ2	20	62046388	G	A	Missense_Mutation	ENST00000370224.1:c.1309C>T	ENSP00000359244.1:p.Arg437Trp	0.14379085
P7-Tissue	TPTE	21	10906981	T	C	Missense_Mutation	ENST00000361285.4:c.1580A>G	ENSP00000355208.4:p.Tyr527Cys	0.0625
P7-Tissue	CCDC116	22	21990791	C	T	Missense_Mutation	ENST00000292779.3:c.1274C>T	ENSP00000292779.3:p.Ser425Phe	0.14925373
P7-Tissue	PLA2G3	22	31533966	C	T	Missense_Mutation	ENST00000215885.3:c.796G>A	ENSP00000215885.3:p.Gly266Ser	0.13274336
P7-Tissue	RBM10	X	47044712	CGA	C	Frame_Shift_Del	ENST00000377604.3:c.2117_2118del	ENSP00000366829.3:p.Arg706ThrfsTer13	0.28125

Organoid

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P7-Organoid	SYTL1	1	27680300	A	C	Missense_Mutation	ENST00000543823.1:c.1646A>C	ENSP00000440704.1:NA	0.07142857
P7-Organoid	RNF19B	1	33407859	T	C	Missense_Mutation	ENST00000373456.7:c.1607A>G	ENSP00000362555.7:NA	0.03636363
P7-Organoid	NRD1	1	52302108	G	C	Missense_Mutation	ENST00000539524.1:c.371C>G	ENSP00000444416.1:NA	0.05952381
P7-Organoid	C1orf173	1	75078419	C	T	Missense_Mutation	ENST00000420661.2:c.484G>A	ENSP00000398581.2:p.Val162Met	0.05964912
P7-Organoid	LHX8	1	75606668	A	T	Splice_Site	ENST00000356261.3:c.238-2A>T		0.05325443
P7-Organoid	SORT1	1	109870162	G	A	Missense_Mutation	ENST00000538502.1:c.1022C>T	ENSP00000438597.1:p.Pro341Leu	0.04780114
P7-Organoid	PGLYRP3	1	153274991	G	T	Missense_Mutation	ENST00000290722.1:c.622C>A	ENSP00000290722.1:p.His208Asn	0.07563025
P7-Organoid	SELE	1	169698391	C	G	Missense_Mutation	ENST00000367782.4:c.1026G>C	ENSP00000356756.4:p.Gln342His	0.08333333
P7-Organoid	SLC9C2	1	173517586	A	T	Missense_Mutation	ENST00000536496.1:c.1097T>A	ENSP00000445437.1:p.Ile366Asn	0.04225352
P7-Organoid	PPP1R15B	1	204380414	CGG	C	Frame_Shift_Del	ENST00000367188.4:c.124_125del	ENSP00000356156.4:p.Pro42GlyfsTer99	0.03267973
P7-Organoid	OR2G6	1	248685273	C	T	Missense_Mutation	ENST00000343414.4:c.326C>T	ENSP00000341291.4:p.Ser109Leu	0.07272727
P7-Organoid	FANCL	2	58390605	T	C	Missense_Mutation	ENST00000403676.1:c.388A>G	ENSP00000384046.1:p.Met130Val	0.11805555
P7-Organoid	FAHD2B	2	97751493	T	A	Missense_Mutation	ENST00000440566.2:c.628A>T	ENSP00000444599.1:p.Thr210Ser	0.03162055
P7-Organoid	REV1	2	100055536	T	C	Missense_Mutation	ENST00000393445.3:c.740A>G	ENSP00000377091.3:p.Asn247Ser	0.03047091
P7-Organoid	TMEM87B	2	112849325	A	G	Missense_Mutation	ENST00000283206.4:c.1069A>G	ENSP00000283206.4:p.Ile357Val	0.06730769
P7-Organoid	PLEKHA3	2	179350416	A	G	Missense_Mutation	ENST00000234453.5:c.89A>G	ENSP00000234453.4:p.Tyr30Cys	0.09061488
P7-Organoid	STAT4	2	191922752	G	A	Nonsense_Mutation	ENST00000392320.2:c.1198C>T	ENSP00000376134.2:p.Arg400Ter	0.04193548
P7-Organoid	JAGN1	3	9934655	T	A	Missense_Mutation	ENST00000307768.4:c.146T>A	ENSP00000306106.4:p.Leu49Gln	0.15972222
P7-Organoid	XPC	3	14199810	T	C	Missense_Mutation	ENST00000449060.2:c.1462A>G	ENSP00000404002.2:p.Ile488Val	0.09606986
P7-Organoid	GOLGB1	3	121416954	G	C	Missense_Mutation	ENST00000393667.3:c.2416C>G	ENSP00000377275.3:p.Leu806Val	0.06640625
P7-Organoid	CLSTN2	3	140282932	A	T	Missense_Mutation	ENST00000458420.3:c.2612A>T	ENSP00000402460.2:p.Glu871Val	0.13941018
P7-Organoid	P2RY14	3	150931753	C	T	Missense_Mutation	ENST00000424796.2:c.352G>A	ENSP00000408733.2:p.Asp118Asn	0.05714285
P7-Organoid	ACOX3	4	8391440	C	CT	Frame_Shift_Ins	ENST00000503233.1:c.1321dup	ENSP00000421625.1:p.Arg441LysfsTer3	0.19557195
P7-Organoid	BMPR1B	4	96035902	G	T	Nonsense_Mutation	ENST00000515059.1:c.175G>T	ENSP00000426617.1:p.Glu59Ter	0.01440922
P7-Organoid	TRIM2	4	154245284	A	G	Missense_Mutation	ENST00000437508.2:c.1925A>G	ENSP00000415812.2:p.His642Arg	0.02479338
P7-Organoid	IRX2	5	2751442	GC	TT	Missense_Mutation	ENST00000382611.6:c.85_86delinsAA	ENSP00000372056.6:p.Ala29Lys	0.07303370
P7-Organoid	BMP6	6	7727471	C	T	Missense_Mutation	ENST00000283147.6:c.283C>T	ENSP00000283147.6:p.Pro95Ser	0.04268292
P7-Organoid	TUBB	6	30690320	G	T	Nonsense_Mutation	ENST00000435534.1:c.64G>T	ENSP00000391672.1:p.Glu22Ter	0.01818181
P7-Organoid	PKHD1	6	51921570	T	C	Missense_Mutation	ENST00000371117.3:c.1619A>G	ENSP00000360158.3:p.Glu540Gly	0.05921052
P7-Organoid	DST	6	56394544	T	C	Missense_Mutation	ENST00000446842.2:c.15692A>G	ENSP00000393645.2:p.Asn5231Ser	0.06091370
P7-Organoid	RIMS1	6	72892678	A	T	Missense_Mutation	ENST00000522291.1:c.1504A>T	ENSP00000430932.1:p.Ser502Cys	0.09160305
P7-Organoid	CEP57L1	6	109480613	A	G	Missense_Mutation	ENST00000523787.1:c.973A>G	ENSP00000430529.1:p.Asn325Asp	0.08675799
P7-Organoid	BCLAF1	6	136599262	A	T	Missense_Mutation	ENST00000531224.1:c.757T>A	ENSP00000435210.1:p.Ser253Thr	0.03869047
P7-Organoid	ADAP1	7	940234	T	C	Missense_Mutation	ENST00000539900.1:c.701A>G	ENSP00000442682.1:p.Asn234Ser	0.07399103
P7-Organoid	AHR	7	17369610	T	C	Missense_Mutation	ENST00000242057.4:c.485T>C	ENSP00000242057.4:p.Ile162Thr	0.04816513
P7-Organoid	NT5C3A	7	33054388	T	C	Missense_Mutation	ENST00000610140.1:c.950A>G	ENSP00000476480.1:p.Asp317Gly	0.08530805
P7-Organoid	KIAA1324L	7	86547844	T	A	Missense_Mutation	ENST00000450689.2:c.1507A>T	ENSP00000413445.2:p.Thr503Ser	0.04823151
P7-Organoid	IKBKB	8	42176153	G	A	Missense_Mutation	ENST00000520835.1:c.1318G>A	ENSP00000430868.1:p.Glu440Lys	0.09859154
P7-Organoid	KDM4C	9	6814711	A	G	Missense_Mutation	ENST00000543771.1:c.401A>G	ENSP00000445427.1:p.Tyr134Cys	0.03137254
P7-Organoid	IFNA4	9	21187439	C	G	Missense_Mutation	ENST00000421715.1:c.92G>C	ENSP00000412897.1:p.Ser31Thr	0.11344537
P7-Organoid	ANKRD20A4	9	69423641	T	G	Missense_Mutation	ENST00000357336.3:c.1937T>G	ENSP00000349891.3:p.Met646Arg	0.18867924
P7-Organoid	FAM120A	9	96320935	C	A	Missense_Mutation	ENST00000333936.5:c.2825C>A	ENSP00000334918.5:p.Ala942Glu	0.00742115
P7-Organoid	LHX6	9	124976268	G	T	Missense_Mutation	ENST00000559895.1:c.216C>A	ENSP00000475927.1:p.Ser72Arg	0.04
P7-Organoid	OR1J1	9	125240148	G	A	Missense_Mutation	ENST00000259357.2:c.58C>T	ENSP00000259357.2:p.Arg20Trp	0.17607223
P7-Organoid	C9orf96	9	136256566	G	C	Missense_Mutation	ENST00000371957.3:c.577G>C	ENSP00000361025.3:p.Glu193Gln	0.053125
P7-Organoid	RBP3	10	48390019	C	T	Missense_Mutation	ENST00000224600.4:c.859G>A	ENSP00000224600.4:p.Gly287Arg	0.05610561
P7-Organoid	BTAF1	10	93786402	G	GC	Frame_Shift_Ins	ENST00000544642.1:c.1615dup	ENSP00000439924.1:p.Leu539ProfsTer4	0.15094339
P7-Organoid	ANO9	11	428548	T	C	Missense_Mutation	ENST00000332826.6:c.1112A>G	ENSP00000332788.6:p.Glu371Gly	0.00814664
P7-Organoid	MUC6	11	1015868	GGT	G	Frame_Shift_Del	ENST00000421673.2:c.6931_6932del	ENSP00000406861.2:p.Thr2311LeufsTer62	0.09545454
P7-Organoid	MUC5B	11	1265872	G	A	Missense_Mutation	ENST00000529681.1:c.7762G>A	ENSP00000436812.1:p.Gly2588Arg	0.14906832
P7-Organoid	OR52B2	11	6191202	C	A	Missense_Mutation	ENST00000530810.1:c.355G>T	ENSP00000432011.1:p.Ala119Ser	0.09126984
P7-Organoid	BBOX1	11	27137073	C	T	Missense_Mutation	ENST00000529202.1:c.608C>T	ENSP00000435781.1:p.Thr203Ile	0.05919003
P7-Organoid	IGHMBP2	11	68682399	T	A	Missense_Mutation	ENST00000255078.3:c.820T>A	ENSP00000255078.3:p.Ser274Thr	0.15811965
P7-Organoid	C2CD2L	11	118986853	A	G	Missense_Mutation	ENST00000336702.3:c.2011A>G	ENSP00000338885.3:p.Thr671Ala	0.05483871
P7-Organoid	CCDC15	11	124824708	A	T	Missense_Mutation	ENST00000529051.1:c.80A>T	ENSP00000435403.1:p.Asp27Val	0.02214022
P7-Organoid	KRAS	12	25378647	T	A	Missense_Mutation	ENST00000311936.3:c.351A>T	ENSP00000308495.3:p.Lys117Asn	0.22268907
P7-Organoid	ABCC4	13	95859021	T	C	Missense_Mutation	ENST00000536256.1:c.701A>G	ENSP00000442024.1:p.Lys234Arg	0.08
P7-Organoid	TEP1	14	20852557	T	G	Missense_Mutation	ENST00000556935.1:c.3008A>C	ENSP00000452574.1:p.Tyr1003Ser	0.10559006
P7-Organoid	RP11-176H8.1	14	31926584	G	A	Missense_Mutation	ENST00000547378.1:c.16C>T	ENSP00000447056.1:p.Arg6Trp	0.125
P7-Organoid	ZFP36L1	14	69256921	T	C	Missense_Mutation	ENST00000439696.2:c.346A>G	ENSP00000388402.2:p.Lys116Glu	0.03496503
P7-Organoid	SERPINA10	14	94750370	T	G	Missense_Mutation	ENST00000554723.1:c.1387A>C	ENSP00000450896.1:p.Met463Leu	0.03937007
P7-Organoid	OTUD7A	15	31776509	G	A	Missense_Mutation	ENST00000382902.1:c.1790C>T	ENSP00000372358.1:p.Ser597Leu	0.03680981
P7-Organoid	MEGF11	15	66209294	G	A	Missense_Mutation	ENST00000422354.1:c.2087C>T	ENSP00000414475.1:p.Ala696Val	0.04113110
P7-Organoid	CEMP1	16	2580757	C	CT	Frame_Shift_Ins	ENST00000567119.1:c.317dup	ENSP00000457380.1:p.Ala107GlyfsTer34	0.12142857
P7-Organoid	CNOT1	16	58566209	T	C	Missense_Mutation	ENST00000569240.1:c.5971A>G	ENSP00000455635.1:p.Met1991Val	0.04802259
P7-Organoid	ZFHX3	16	72992026	GC	AT	Missense_Mutation	ENST00000268489.5:c.2018_2019delinsAT	ENSP00000268489.5:p.Cys673Tyr	0.08620689
P7-Organoid	SPIRE2	16	89922552	C	T	Missense_Mutation	ENST00000393062.2:c.1010C>T	ENSP00000376782.2:p.Pro337Leu	0.18360655
P7-Organoid	C17orf74	17	7329786	G	A	Missense_Mutation	ENST00000333870.3:c.476G>A	ENSP00000328061.3:p.Arg159His	0.03466666
P7-Organoid	SAT2	17	7530323	T	C	Missense_Mutation	ENST00000269298.5:c.242A>G	ENSP00000269298.5:p.Tyr81Cys	0.03802281
P7-Organoid	SUPT6H	17	27011695	AC	A	Frame_Shift_Del	ENST00000347486.4:c.2323del	ENSP00000338143.4:p.Gln775LysfsTer31	0.05210918
P7-Organoid	SUPT6H	17	27011697	C	A	Missense_Mutation	ENST00000347486.4:c.2323C>A	ENSP00000338143.4:p.Gln775Lys	0.05459057
P7-Organoid	TRAF4	17	27075557	C	G	Missense_Mutation	ENST00000444415.3:c.653C>G	ENSP00000438154.2:p.Pro218Arg	0.01782178
P7-Organoid	EFCAB5	17	28380548	C	G	Missense_Mutation	ENST00000541045.1:c.547C>G	ENSP00000445575.1:p.Gln183Glu	0.11945392
P7-Organoid	UBTF	17	42295555	C	T	Missense_Mutation	ENST00000533177.1:c.43G>A	ENSP00000437180.1:p.Ala15Thr	0.04528301
P7-Organoid	GRN	17	42429029	C	A	Missense_Mutation	ENST00000589265.1:c.574C>A	ENSP00000467616.1:p.Pro192Thr	0.02777777
P7-Organoid	SLC35B1	17	47783663	C	T	Missense_Mutation	ENST00000415270.2:c.353G>A	ENSP00000409548.2:p.Arg118His	0.07936507
P7-Organoid	COX11	17	53042092	T	C	Missense_Mutation	ENST00000571584.1:c.488A>G	ENSP00000460043.1:p.Gln163Arg	0.05405405
P7-Organoid	KLHL14	18	30350347	C	T	Missense_Mutation	ENST00000359358.4:c.208G>A	ENSP00000352314.4:p.Gly70Arg	0.14184397
P7-Organoid	ONECUT3	19	1754119	C	A	Missense_Mutation	ENST00000382349.4:c.458C>A	ENSP00000371786.4:p.Pro153Gln	0.04301075
P7-Organoid	LONP1	19	5719993	G	T	Missense_Mutation	ENST00000360614.3:c.151C>A	ENSP00000353826.2:p.Pro51Thr	0.07407407
P7-Organoid	EMR1	19	6937417	G	C	Missense_Mutation	ENST00000450315.3:c.2014G>C	ENSP00000405974.2:p.Gly672Arg	0.03643724
P7-Organoid	ICAM1	19	10395308	C	A	Missense_Mutation	ENST00000423829.2:c.489C>A	ENSP00000413124.2:p.Asn163Lys	0.04421768
P7-Organoid	UQCRFS1	19	29698549	T	C	Missense_Mutation	ENST00000304863.4:c.731A>G	ENSP00000306397.3:p.Asp244Gly	0.15923566
P7-Organoid	UQCRFS1	19	29698558	GACCCATGGCAAGGGCAGTAATAACCACCAAA	G	Frame_Shift_Del	ENST00000304863.4:c.691_721del	ENSP00000306397.3:p.Phe231HisfsTer31	0.07023411
P7-Organoid	LTBP4	19	41111469	A	G	Missense_Mutation	ENST00000396819.3:c.601A>G	ENSP00000380031.3:p.Thr201Ala	0.03103448
P7-Organoid	LMTK3	19	49002945	C	T	Missense_Mutation	ENST00000600059.1:c.1381G>A	ENSP00000472020.1:p.Asp461Asn	0.07390300
P7-Organoid	NOP56	20	2638617	CAGGAGG	C	In_Frame_Del	ENST00000329276.5:c.1463_1468del	ENSP00000370589.3:p.Gln488_Val490delinsLeu	0.02710843
P7-Organoid	PLCB4	20	9319560	C	G	Missense_Mutation	ENST00000414679.2:c.245C>G	ENSP00000390616.2:p.Ala82Gly	0.04727272
P7-Organoid	ZNFX1	20	47864431	G	C	Missense_Mutation	ENST00000396105.1:c.5130C>G	ENSP00000379412.1:p.Asp1710Glu	0.06228373
P7-Organoid	PARD6B	20	49366963	T	G	Missense_Mutation	ENST00000371610.2:c.1057T>G	ENSP00000360672.2:p.Phe353Val	0.08098591
P7-Organoid	PCNT	21	47818027	G	T	Missense_Mutation	ENST00000359568.5:c.4546G>T	ENSP00000352572.5:p.Gly1516Cys	0.01557632
P7-Organoid	PATZ1	22	31724805	G	A	Missense_Mutation	ENST00000266269.5:c.1613C>T	ENSP00000266269.5:p.Ala538Val	0.10089020
P7-Organoid	PTCHD1	X	23412234	G	A	Missense_Mutation	ENST00000379361.4:c.2599G>A	ENSP00000368666.4:p.Glu867Lys	0.03225806
P7-Organoid	COL4A5	X	107849993	C	T	Missense_Mutation	ENST00000361603.2:c.2266C>T	ENSP00000354505.2:p.Pro756Ser	0.08860759

Somatic Copy Number Alterations

Primary Tumor

Organoid

Concordance between Primary tumor and Organoid

VAF-VAF Plot

Number of Shared Mutations between Primary tumor and organoid (All mutations)

Number of Shared Mutations between Primary tumor and organoid (Functional mutations)

Drug Responses

ID	Drug	IC50
P7	AZD2014	~ 1256
P7	AZD3759	442.6
P7	AZD4547	~ 1.580e+014
P7	AZD5363	9394
P7	AZD6738	1694
P7	AZD9291	155.7
P7	I.BET.762	375.4
P7	Rapamycin..Sirolimus.	135
P7	AZD1775..MK.1775.	1423
P7	Triptolide..PG490.	4.254
P7	Simvastatin	~ 0.0005687
P7	Temozolomide	~ 25758
P7	Imatinib.Mesylate..STI571.	~ 6344
P7	Pazopanib..GW786034.	~ 5366
P7	Sunitinib.Malate	~ 5080
P7	Olaparib..AZD2281..KU0059436.	~ 58911
P7	Regorafenib..BAY.73.4506.	1154
P7	Erlotinib	996.1
P7	Gefitinib	306.4
P7	Afatinib	~ 3.288e-006
P7	OTX.015	147.2
P7	BKM120..NVP.BKM120.	6604
P7	BYL719	11865
P7	Cediranib..AZD2171.	~ 34680
P7	Ceritinib.LDK378.	219.1
P7	Crizotinib...PF.02341066.	3374
P7	Dabrafenib	2924
P7	Dacomitinib	~ 18.76
P7	Everolimus..RAD001.	253.2
P7	Ibrutinib..PCI.32765.	119.2
P7	Lapatinib	173.3
P7	LY2835219	242.3
P7	Brivanib..BMS.582664.	~ 18344
P7	Panobinostat	29.12
P7	Selumetinib..AZD6244.	~ 72.96
P7	Sorafenib	~
P7	Trametinib	7.043
P7	Vandetanib..ZD6474.	~ 1237
P7	Vemurafenib	~ 0.000
P7	AZD5153	84.68
P7	ABT.199..GDC.0199..	~ 2793
P7	ABT.888..Veliparib..NSC.737664.	3119
P7	Avagacestat..BMS.708163.	107.6
P7	Axitinib...AG.013736.	1664
P7	Bosutinib..SKI.606.	907.7
P7	Cabozantinib..XL184.	~ 4681
P7	Dasatinib..BMS.354825.	9.687
P7	decitabine	~ 3.191e-016
P7	defactinib	17.12
P7	Dovitinib..TKI258.CHIR258.	~ 1.120e+015
P7	Fluorouracil..5.Fluoracil..5.FU.	2075
P7	Foretinib..XL880.	977.7
P7	Tivantinib..ARQ.197.	162
P7	Abraxane	~ 0.0002235
P7	AZD2461.olaparib.analog.	~ 1.410e-006
P7	Olaparib.	~ 6.530e-008
P7	Idelalisib	~ 1182814
P7	Irinotecan	13297
P7	Nilotinib..AMN.107.	~ 19.13
P7	NVP.AEW541	1206
P7	Oxaliplatin	~ 0.000
P7	PLX3397	~ 1064
P7	Quizartinib..AC220.	~ 27355
P7	Saracatinib..AZD0530.	1095
P7	Semagacestat..LY450139.	1043
P7	TGX.221	~ 22265
P7	tozasertib	~ 4.756e-005
P7	Vorinostat..SAHA..MK0683.	961.5
P7	XAV939	942.3
P7	gemcitabine	668.1
P7	palbociclib	~ 8.981e+021
P7	Neratinib..HKI.272.	250.3