Organoidomics

Please contact Prof. Semin Lee, Jinho Jang or Web-master for any inquires.

3D Organoids

RAMP

Clinical Information

ID	Diagnosis	Stage	Age	BMI	Sex	CA19-9
P6	PDAC	4	62	20.7	Female	115048

Mutation Profiles

Primary Tumor

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P6-Tissue	ATAD3B	1	1431060	T	C	Missense_Mutation	ENST00000308647.7:c.1810T>C	ENSP00000311766.7:p.Tyr604His	0.23333333
P6-Tissue	MEGF6	1	3422096	G	A	Missense_Mutation	ENST00000356575.4:c.1943C>T	ENSP00000348982.4:p.Pro648Leu	0.32900432
P6-Tissue	PRAMEF1	1	12855774	A	G	Missense_Mutation	ENST00000400814.3:c.319A>G	ENSP00000383616.3:p.Lys352Glu	0.14954955
P6-Tissue	C1QB	1	22987700	GT	AC	Missense_Mutation	ENST00000509305.1:c.577_578inv	ENSP00000423689.1:p.Val195Thr	0.06140350
P6-Tissue	HYI	1	43917177	G	A	Missense_Mutation	ENST00000583037.1:c.445C>T	ENSP00000461969.1:p.Pro222Ser	0.03174603
P6-Tissue	SYPL2	1	110019476	C	A	Missense_Mutation	ENST00000401021.3:c.333C>A	ENSP00000383805.3:p.Phe111Leu	0.40828402
P6-Tissue	LRIF1	1	111493982	C	A	Missense_Mutation	ENST00000369763.4:c.1524G>T	ENSP00000358778.4:p.Glu508Asp	0.28571428
P6-Tissue	NBPF20	1	148343792	C	A	Missense_Mutation	ENST00000414710.2:c.295G>T	ENSP00000389520.2:p.Val99Phe	0.15730337
P6-Tissue	CRP	1	159683629	C	T	Missense_Mutation	ENST00000255030.5:c.361G>A	ENSP00000255030.5:p.Ala121Thr	0.20149253
P6-Tissue	DISP1	1	223116620	C	T	Missense_Mutation	ENST00000360254.2:c.455C>T	ENSP00000355848.1:p.Pro152Leu	0.27049180
P6-Tissue	OR2T33	1	248436809	G	A	Missense_Mutation	ENST00000318021.2:c.308C>T	ENSP00000324687.2:p.Pro103Leu	0.10905730
P6-Tissue	DNMT3A	2	25469175	T	A	Missense_Mutation	ENST00000402667.1:c.614A>T	ENSP00000384237.1:p.Glu205Val	0.22543352
P6-Tissue	CRIM1	2	36726432	C	A	Missense_Mutation	ENST00000280527.2:c.1443C>A	ENSP00000280527.2:p.Asp481Glu	0.20737327
P6-Tissue	SRBD1	2	45647006	C	T	Missense_Mutation	ENST00000535761.1:c.634G>A	ENSP00000441272.1:p.Ala212Thr	0.00826446
P6-Tissue	LIMS1	2	109276221	G	T	Splice_Site	ENST00000544547.1:c.192+1G>T		0.28695652
P6-Tissue	ANAPC1	2	112614429	G	A	Nonsense_Mutation	ENST00000341068.3:c.1393C>T	ENSP00000339109.3:p.Gln465Ter	0.17081850
P6-Tissue	CYP27C1	2	127957056	T	A	Missense_Mutation	ENST00000409327.1:c.448A>T	ENSP00000387198.1:p.Arg150Trp	0.21428571
P6-Tissue	LRP1B	2	141215143	T	A	Nonsense_Mutation	ENST00000389484.3:c.9703A>T	ENSP00000374135.3:p.Lys3235Ter	0.26267281
P6-Tissue	SLC38A11	2	165765214	AC	GT	Missense_Mutation	ENST00000409662.1:c.862_863inv	ENSP00000386774.1:p.Val288Thr	0.03389830
P6-Tissue	PIKFYVE	2	209212650	CCA	TGG	Missense_Mutation	ENST00000264380.4:c.5277_5279inv	ENSP00000264380.4:p.Gln1760Gly	0.00869565
P6-Tissue	OXSM	3	25833153	T	G	Missense_Mutation	ENST00000420173.2:c.642T>G	ENSP00000411303.2:p.His214Gln	0.01369863
P6-Tissue	PROS1	3	93646128	T	G	Missense_Mutation	ENST00000394236.3:c.200A>C	ENSP00000377783.3:p.Glu67Ala	0.07
P6-Tissue	OR5H14	3	97868683	G	C	Missense_Mutation	ENST00000437310.1:c.454G>C	ENSP00000401706.1:p.Gly152Arg	0.14669926
P6-Tissue	KPNA1	3	122145899	A	G	Missense_Mutation	ENST00000344337.6:c.1550T>C	ENSP00000343701.6:p.Val517Ala	0.23394495
P6-Tissue	C3orf70	3	184870580	C	A	Missense_Mutation	ENST00000335012.2:c.32G>T	ENSP00000334974.2:p.Arg11Leu	0.18932038
P6-Tissue	HELQ	4	84362556	CC	GG	Splice_Site	ENST00000510985.1:c.1363-1_1363inv		0.01851851
P6-Tissue	DCHS2	4	155237005	C	A	Missense_Mutation	ENST00000357232.4:c.3790G>T	ENSP00000349768.3:p.Asp1264Tyr	0.0625
P6-Tissue	DCHS2	4	155254556	C	T	Missense_Mutation	ENST00000357232.4:c.1307G>A	ENSP00000349768.3:p.Arg436Gln	0.03433476
P6-Tissue	FSTL5	4	162421217	C	T	Missense_Mutation	ENST00000536695.1:c.1406G>A	ENSP00000440409.1:p.Cys469Tyr	0.26506024
P6-Tissue	ZDHHC11	5	843816	GA	TC	Missense_Mutation	ENST00000424784.2:c.526_527inv	ENSP00000397719.2:p.Ser176Glu	0.008
P6-Tissue	CCNO	5	54527501	G	A	Missense_Mutation	ENST00000282572.4:c.755C>T	ENSP00000282572.4:p.Ala252Val	0.29268292
P6-Tissue	HOMER1	5	78752778	GTTC	G	In_Frame_Del	ENST00000508576.1:c.66_68del	ENSP00000426651.1:p.Lys22del	0.22077922
P6-Tissue	APC	5	112174319	A	T	Missense_Mutation	ENST00000508376.2:c.3028A>T	ENSP00000427089.2:p.Ser1010Cys	0.01415094
P6-Tissue	AP3S1	5	115249078	C	T	Missense_Mutation	ENST00000316788.7:c.473C>T	ENSP00000325369.7:p.Pro158Leu	0.28823529
P6-Tissue	FCHSD1	5	141029021	G	A	Nonsense_Mutation	ENST00000522783.1:c.310C>T	ENSP00000428677.1:p.Arg104Ter	0.22432432
P6-Tissue	HLA-C	6	31239598	G	T	Missense_Mutation	ENST00000383329.3:c.121C>A	ENSP00000372819.3:p.Arg41Ser	0.06306306
P6-Tissue	LATS1	6	150016266	C	T	Missense_Mutation	ENST00000543571.1:c.440G>A	ENSP00000437550.1:p.Arg147Gln	0.09
P6-Tissue	RSPH3	6	159401898	C	T	Missense_Mutation	ENST00000449822.1:c.479G>A	ENSP00000393195.1:p.Arg160Gln	0.34782608
P6-Tissue	HOXA5	7	27183114	G	A	Missense_Mutation	ENST00000222726.3:c.113C>T	ENSP00000222726.3:p.Ala38Val	0.16363636
P6-Tissue	PDE1C	7	31918637	C	T	Missense_Mutation	ENST00000396193.1:c.577G>A	ENSP00000379496.1:p.Ala193Thr	0.16666666
P6-Tissue	MUC3A	7	100552060	A	T	Missense_Mutation	ENST00000319509.7:c.811A>T	ENSP00000324834.7:p.Ser271Cys	0.05590062
P6-Tissue	SMO	7	128829134	G	A	Missense_Mutation	ENST00000249373.3:c.142G>A	ENSP00000249373.3:p.Ala48Thr	0.30612244
P6-Tissue	OR2A14	7	143826836	T	A	Missense_Mutation	ENST00000408899.2:c.631T>A	ENSP00000386137.2:p.Cys211Ser	0.28571428
P6-Tissue	ABRA	8	107782411	G	A	Missense_Mutation	ENST00000311955.3:c.8C>T	ENSP00000311436.3:p.Pro3Leu	0.16883116
P6-Tissue	GALT	9	34648781	AG	CT	Missense_Mutation	ENST00000450095.2:c.383_384inv	ENSP00000401956.2:p.Glu128Ala	0.07070707
P6-Tissue	CDH23	10	73462377	G	C	Missense_Mutation	ENST00000299366.7:c.2794G>C	ENSP00000299366.7:p.Asp932His	0.16205533
P6-Tissue	NUTM2A	10	88988593	C	T	Missense_Mutation	ENST00000381707.2:c.956C>T	ENSP00000371126.1:p.Pro319Leu	0.27160493
P6-Tissue	PDCD11	10	105181274	A	T	Missense_Mutation	ENST00000369797.3:c.2447A>T	ENSP00000358812.3:p.Asn816Ile	0.00628930
P6-Tissue	IFITM3	11	320606	G	T	Missense_Mutation	ENST00000602735.1:c.145C>A	ENSP00000473544.1:p.Pro49Thr	0.08099688
P6-Tissue	OR5J2	11	55944161	T	A	Missense_Mutation	ENST00000312298.1:c.68T>A	ENSP00000310788.1:p.Leu23Gln	0.05806451
P6-Tissue	GUCY1A2	11	106810250	C	T	Missense_Mutation	ENST00000526355.2:c.1142G>A	ENSP00000431245.1:p.Arg381Gln	0.28571428
P6-Tissue	PPP2R1B	11	111622992	C	T	Missense_Mutation	ENST00000527614.1:c.1229G>A	ENSP00000437193.1:p.Arg410His	0.11538461
P6-Tissue	KRAS	12	25398284	C	T	Missense_Mutation	ENST00000557334.1:c.35G>A	ENSP00000452512.1:p.Gly12Asp	0.33888888
P6-Tissue	OVCH1	12	29604469	CT	AG	Missense_Mutation	ENST00000318184.5:c.2563_2564inv	ENSP00000326708.5:p.Arg855Leu	0.01401869
P6-Tissue	MIP	12	56848113	CA	TG	Missense_Mutation	ENST00000257979.4:c.284_285inv	ENSP00000257979.4:p.Leu95Pro	0.00729927
P6-Tissue	PTPRB	12	70918319	T	C	Missense_Mutation	ENST00000550857.1:c.5633A>G	ENSP00000447302.1:p.Lys1878Arg	0.36440678
P6-Tissue	CCDC38	12	96284657	C	T	Missense_Mutation	ENST00000344280.3:c.824G>A	ENSP00000345470.3:p.Arg275Lys	0.2625
P6-Tissue	ZC3H13	13	46549496	C	A	Missense_Mutation	ENST00000282007.3:c.2390G>T	ENSP00000282007.3:p.Arg797Leu	0.09183673
P6-Tissue	RYR3	15	33905503	G	A	Missense_Mutation	ENST00000415757.3:c.2284G>A	ENSP00000399610.3:p.Val762Met	0.06109324
P6-Tissue	POLG	15	89860634	T	A	Missense_Mutation	ENST00000442287.2:c.3616A>T	ENSP00000399851.2:p.Met1206Leu	0.00684931
P6-Tissue	SYNM	15	99672797	C	T	Missense_Mutation	ENST00000336292.6:c.4229C>T	ENSP00000336775.6:p.Thr1410Met	0.29007633
P6-Tissue	CACNA1H	16	1270607	CAC	GTG	Missense_Mutation	ENST00000565831.1:c.6657_6659inv	ENSP00000455840.1:p.Thr2220Trp	0.02068965
P6-Tissue	TPSG1	16	1271959	G	C	Missense_Mutation	ENST00000234798.4:c.795C>G	ENSP00000234798.4:p.Ile265Met	0.21404682
P6-Tissue	TP53	17	7578406	C	T	Missense_Mutation	ENST00000455263.2:c.524G>A	ENSP00000398846.2:p.Arg175His	0.29239766
P6-Tissue	CCDC43	17	42766975	CTGCAGGATACCCA	C	Frame_Shift_Del	ENST00000588210.1:c.134_146del	ENSP00000467630.1:p.Leu45TrpfsTer46	0.09663865
P6-Tissue	MYCBPAP	17	48586027	GG	CC	Missense_Mutation	ENST00000436259.2:c.10_11inv	ENSP00000397209.2:p.Gly4Pro	0.01680672
P6-Tissue	ANKFN1	17	54559838	C	T	Missense_Mutation	ENST00000566473.2:c.2222C>T	ENSP00000454224.2:p.Thr741Ile	0.25233644
P6-Tissue	DSG2	18	29118830	GTT	AAC	Missense_Mutation	ENST00000261590.8:c.1768_1770inv	ENSP00000261590.8:p.Val590Asn	0.00666666
P6-Tissue	SMAD4	18	48591975	A	T	Missense_Mutation	ENST00000588745.1:c.850A>T	ENSP00000464901.1:p.Arg284Trp	0.42657342
P6-Tissue	RPS15	19	1440068	G	C	Missense_Mutation	ENST00000593052.1:c.161G>C	ENSP00000466010.1:p.Arg54Pro	0.28235294
P6-Tissue	SAFB	19	5650989	G	C	Missense_Mutation	ENST00000592224.1:c.1199G>C	ENSP00000464840.1:p.Gly400Ala	0.16091954
P6-Tissue	ZNF560	19	9578164	G	A	Missense_Mutation	ENST00000301480.4:c.1459C>T	ENSP00000301480.3:p.Arg487Cys	0.14492753
P6-Tissue	MAST3	19	18249866	G	A	Missense_Mutation	ENST00000262811.6:c.2050G>A	ENSP00000262811.4:p.Glu684Lys	0.27848101
P6-Tissue	CYP2A13	19	41595958	CG	TA	Missense_Mutation	ENST00000330436.3:c.350_351delinsTA	ENSP00000332679.1:p.Ala117Val	0.03825136
P6-Tissue	CIC	19	42794415	A	T	Missense_Mutation	ENST00000575354.2:c.1495A>T	ENSP00000458663.2:p.Ile499Phe	0.12925170
P6-Tissue	SIGLEC10	19	51920196	G	T	Missense_Mutation	ENST00000525998.1:c.430C>A	ENSP00000431444.1:p.Gln144Lys	0.12969283
P6-Tissue	SIGLEC14	19	52146840	C	T	Missense_Mutation	ENST00000360844.6:c.1098G>A	ENSP00000354090.5:p.Met366Ile	0.37333333
P6-Tissue	KIR3DL1	19	55329854	G	A	Missense_Mutation	ENST00000541392.1:c.155G>A	ENSP00000442355.1:p.Arg52His	0.11805555
P6-Tissue	PCSK2	20	17462414	G	A	Missense_Mutation	ENST00000536609.1:c.1511G>A	ENSP00000437458.1:p.Arg504His	0.08333333
P6-Tissue	SLC12A5	20	44669254	G	A	Splice_Site	ENST00000454036.2:c.923+1G>A		0.28703703
P6-Tissue	ZFP64	20	50705079	A	T	Nonsense_Mutation	ENST00000371523.4:c.423T>A	ENSP00000360578.4:p.Cys141Ter	0.01538461
P6-Tissue	CYYR1	21	27840906	C	A	Missense_Mutation	ENST00000299340.4:c.379G>T	ENSP00000299340.4:p.Asp127Tyr	0.1
P6-Tissue	MCM5	22	35806828	C	T	Missense_Mutation	ENST00000382011.5:c.715C>T	ENSP00000371441.5:p.Arg239Cys	0.22053231
P6-Tissue	RRP7A	22	42910199	G	A	Missense_Mutation	ENST00000323013.6:c.670C>T	ENSP00000321449.6:p.Arg224Trp	0.103125
P6-Tissue	CXorf21	X	30578114	A	AAG	Frame_Shift_Ins	ENST00000378962.3:c.358_359insCT	ENSP00000368245.3:p.Ile120ThrfsTer16	0.02564102
P6-Tissue	CXorf21	X	30578116	ACT	A	Frame_Shift_Del	ENST00000378962.3:c.355_356del	ENSP00000368245.3:p.Ser119TyrfsTer6	0.02816901
P6-Tissue	KDM6A	X	44929421	GT	G	Frame_Shift_Del	ENST00000543216.1:c.2286del	ENSP00000443078.1:p.Thr763ProfsTer25	0.31791907
P6-Tissue	SYP	X	49049795	G	C	Missense_Mutation	ENST00000538567.1:c.195C>G	ENSP00000437456.1:p.Cys65Trp	0.02645502
P6-Tissue	AWAT1	X	69456944	TC	GA	Missense_Mutation	ENST00000374521.3:c.306_307inv	ENSP00000363645.3:p.His103Asn	0.04195804

Organoid

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P6-Organoid	ATAD3A	1	1452592	T	C	Missense_Mutation	ENST00000378755.5:c.328T>C	ENSP00000368030.5:p.Trp110Arg	1
P6-Organoid	MEGF6	1	3422096	G	A	Missense_Mutation	ENST00000356575.4:c.1943C>T	ENSP00000348982.4:p.Pro648Leu	1
P6-Organoid	CA6	1	9009485	CAACA	C	Frame_Shift_Del	ENST00000480186.3:c.245_248del	ENSP00000435280.1:NA	0.15686274
P6-Organoid	PRAMEF1	1	12855774	A	G	Missense_Mutation	ENST00000400814.3:c.319A>G	ENSP00000383616.3:p.Lys352Glu	0.17361111
P6-Organoid	SYPL2	1	110019476	C	A	Missense_Mutation	ENST00000401021.3:c.333C>A	ENSP00000383805.3:p.Phe111Leu	1
P6-Organoid	LRIF1	1	111493982	C	A	Missense_Mutation	ENST00000369763.4:c.1524G>T	ENSP00000358778.4:p.Glu508Asp	1
P6-Organoid	NBPF20	1	148343792	C	A	Missense_Mutation	ENST00000414710.2:c.295G>T	ENSP00000389520.2:p.Val99Phe	0.19354838
P6-Organoid	CRP	1	159683629	C	T	Missense_Mutation	ENST00000255030.5:c.361G>A	ENSP00000255030.5:p.Ala121Thr	0.45522388
P6-Organoid	CFH	1	196659293	C	A	Nonsense_Mutation	ENST00000439155.2:c.1260C>A	ENSP00000402656.2:NA	0.07421875
P6-Organoid	DISP1	1	223116620	C	T	Missense_Mutation	ENST00000360254.2:c.455C>T	ENSP00000355848.1:p.Pro152Leu	0.54618473
P6-Organoid	ASAP2	2	9347277	A	T	Missense_Mutation	ENST00000315273.4:c.44A>T	ENSP00000316404.4:p.His15Leu	0.07796610
P6-Organoid	DNMT3A	2	25469175	T	A	Missense_Mutation	ENST00000402667.1:c.614A>T	ENSP00000384237.1:p.Glu205Val	0.40909090
P6-Organoid	CRIM1	2	36726432	C	A	Missense_Mutation	ENST00000280527.2:c.1443C>A	ENSP00000280527.2:p.Asp481Glu	0.36690647
P6-Organoid	RHOQ	2	46803760	A	G	Missense_Mutation	ENST00000238738.4:c.427A>G	ENSP00000238738.4:p.Ile143Val	0.02521008
P6-Organoid	REG3A	2	79385866	C	G	Missense_Mutation	ENST00000409839.3:c.106G>C	ENSP00000386630.3:p.Ala36Pro	0.02352941
P6-Organoid	RETSAT	2	85570849	C	T	Missense_Mutation	ENST00000457495.2:c.1423G>A	ENSP00000405040.2:p.Gly475Arg	0.20098039
P6-Organoid	RETSAT	2	85570857	G	A	Missense_Mutation	ENST00000457495.2:c.1415C>T	ENSP00000405040.2:p.Ala472Val	0.22405660
P6-Organoid	LIMS1	2	109276221	G	T	Splice_Site	ENST00000544547.1:c.192+1G>T		0.28643216
P6-Organoid	ANAPC1	2	112614429	G	A	Nonsense_Mutation	ENST00000341068.3:c.1393C>T	ENSP00000339109.3:p.Gln465Ter	0.11240310
P6-Organoid	CYP27C1	2	127957056	T	A	Missense_Mutation	ENST00000409327.1:c.448A>T	ENSP00000387198.1:p.Arg150Trp	0.40284360
P6-Organoid	LRP1B	2	141215143	T	A	Nonsense_Mutation	ENST00000389484.3:c.9703A>T	ENSP00000374135.3:p.Lys3235Ter	0.45901639
P6-Organoid	OR5H14	3	97868683	G	C	Missense_Mutation	ENST00000437310.1:c.454G>C	ENSP00000401706.1:p.Gly152Arg	0.14526315
P6-Organoid	KPNA1	3	122145899	A	G	Missense_Mutation	ENST00000344337.6:c.1550T>C	ENSP00000343701.6:p.Val517Ala	0.42920354
P6-Organoid	C3orf70	3	184870580	C	A	Missense_Mutation	ENST00000335012.2:c.32G>T	ENSP00000334974.2:p.Arg11Leu	0.45522388
P6-Organoid	DGKQ	4	961585	C	A	Missense_Mutation	ENST00000273814.3:c.817G>T	ENSP00000273814.3:p.Gly273Trp	0.02424242
P6-Organoid	ARHGAP10	4	148786045	C	T	Missense_Mutation	ENST00000336498.3:c.535C>T	ENSP00000336923.3:p.Leu179Phe	0.10071942
P6-Organoid	FSTL5	4	162421217	C	T	Missense_Mutation	ENST00000536695.1:c.1406G>A	ENSP00000440409.1:p.Cys469Tyr	0.55737704
P6-Organoid	CCNO	5	54527501	G	A	Missense_Mutation	ENST00000282572.4:c.755C>T	ENSP00000282572.4:p.Ala252Val	0.41176470
P6-Organoid	HOMER1	5	78752778	GTTC	G	In_Frame_Del	ENST00000508576.1:c.66_68del	ENSP00000426651.1:p.Lys22del	0.39230769
P6-Organoid	FCHSD1	5	141029021	G	A	Nonsense_Mutation	ENST00000522783.1:c.310C>T	ENSP00000428677.1:p.Arg104Ter	0.55016181
P6-Organoid	HLA-C	6	31239598	G	T	Missense_Mutation	ENST00000383329.3:c.121C>A	ENSP00000372819.3:p.Arg41Ser	0.08641975
P6-Organoid	RSPH3	6	159401898	C	T	Missense_Mutation	ENST00000449822.1:c.479G>A	ENSP00000393195.1:p.Arg160Gln	1
P6-Organoid	HOXA5	7	27183114	G	A	Missense_Mutation	ENST00000222726.3:c.113C>T	ENSP00000222726.3:p.Ala38Val	0.37878787
P6-Organoid	PDE1C	7	31918637	C	T	Missense_Mutation	ENST00000396193.1:c.577G>A	ENSP00000379496.1:p.Ala193Thr	0.33333333
P6-Organoid	MAGI2	7	77789399	C	T	Missense_Mutation	ENST00000522391.1:c.2788G>A	ENSP00000428389.1:p.Gly930Ser	0.09150326
P6-Organoid	SMO	7	128829134	G	A	Missense_Mutation	ENST00000249373.3:c.142G>A	ENSP00000249373.3:p.Ala48Thr	0.61764705
P6-Organoid	OR2A14	7	143826836	T	A	Missense_Mutation	ENST00000408899.2:c.631T>A	ENSP00000386137.2:p.Cys211Ser	0.74074074
P6-Organoid	ABRA	8	107782411	G	A	Missense_Mutation	ENST00000311955.3:c.8C>T	ENSP00000311436.3:p.Pro3Leu	0.51470588
P6-Organoid	MLLT3	9	20414307	GCTA	G	In_Frame_Del	ENST00000429426.2:c.525_527del	ENSP00000410482.2:p.Ser187del	0.07407407
P6-Organoid	ODF2	9	131256981	A	G	Missense_Mutation	ENST00000546203.1:c.1888A>G	ENSP00000437579.1:p.Thr630Ala	0.01807228
P6-Organoid	ODF2	9	131256999	A	T	Missense_Mutation	ENST00000546203.1:c.1906A>T	ENSP00000437579.1:p.Ile636Leu	0.02068965
P6-Organoid	UNC5B	10	73046531	G	A	Missense_Mutation	ENST00000373192.4:c.638G>A	ENSP00000362288.4:p.Arg213His	0.555
P6-Organoid	CDH23	10	73462377	G	C	Missense_Mutation	ENST00000299366.7:c.2794G>C	ENSP00000299366.7:p.Asp932His	0.35242290
P6-Organoid	NUTM2A	10	88988593	C	T	Missense_Mutation	ENST00000381707.2:c.956C>T	ENSP00000371126.1:p.Pro319Leu	0.16842105
P6-Organoid	PNLIPRP1	10	118368594	G	A	Missense_Mutation	ENST00000534537.1:c.1370G>A	ENSP00000434159.1:p.Arg457Gln	0.11956521
P6-Organoid	IFITM3	11	320606	G	T	Missense_Mutation	ENST00000602735.1:c.145C>A	ENSP00000473544.1:p.Pro49Thr	0.08203125
P6-Organoid	PHF21A	11	45967494	T	G	Missense_Mutation	ENST00000418153.2:c.1346A>C	ENSP00000398824.2:p.Gln449Pro	0.03614457
P6-Organoid	POLA2	11	65036162	G	T	Nonsense_Mutation	ENST00000265465.3:c.316G>T	ENSP00000265465.3:p.Glu106Ter	0.02758620
P6-Organoid	GUCY1A2	11	106810250	C	T	Missense_Mutation	ENST00000526355.2:c.1142G>A	ENSP00000431245.1:p.Arg381Gln	0.63076923
P6-Organoid	PPP2R1B	11	111622992	C	T	Missense_Mutation	ENST00000527614.1:c.1229G>A	ENSP00000437193.1:p.Arg410His	0.26623376
P6-Organoid	KRAS	12	25398284	C	T	Missense_Mutation	ENST00000557334.1:c.35G>A	ENSP00000452512.1:p.Gly12Asp	0.47019867
P6-Organoid	BHLHE41	12	26275210	G	T	Missense_Mutation	ENST00000242728.4:c.1238C>A	ENSP00000242728.4:p.Pro413His	0.04615384
P6-Organoid	DDX11	12	31237967	C	G	Missense_Mutation	ENST00000545668.1:c.545C>G	ENSP00000440402.1:p.Pro182Arg	0.09166666
P6-Organoid	DDX11	12	31237978	C	T	Missense_Mutation	ENST00000545668.1:c.556C>T	ENSP00000440402.1:p.Arg186Trp	0.05490196
P6-Organoid	PTPRB	12	70918319	T	C	Missense_Mutation	ENST00000550857.1:c.5633A>G	ENSP00000447302.1:p.Lys1878Arg	1
P6-Organoid	CCDC38	12	96284657	C	T	Missense_Mutation	ENST00000344280.3:c.824G>A	ENSP00000345470.3:p.Arg275Lys	0.97894736
P6-Organoid	PPP1CC	12	111160344	A	G	Missense_Mutation	ENST00000551676.1:c.680T>C	ENSP00000448437.1:p.Phe227Ser	0.0703125
P6-Organoid	CLIP1	12	122835680	T	G	Missense_Mutation	ENST00000540338.1:c.1379A>C	ENSP00000439093.1:p.Gln460Pro	0.04
P6-Organoid	DACH1	13	72440661	C	T	Missense_Mutation	ENST00000359684.2:c.247G>A	ENSP00000352712.2:p.Gly83Ser	0.11538461
P6-Organoid	HERC2	15	28447282	CG	TA	Missense_Mutation	ENST00000261609.7:c.7593_7594delinsTA	ENSP00000261609.7:p.Val2532Met	0.17171717
P6-Organoid	SYNM	15	99672797	C	T	Missense_Mutation	ENST00000336292.6:c.4229C>T	ENSP00000336775.6:p.Thr1410Met	0.59006211
P6-Organoid	TPSG1	16	1271959	G	C	Missense_Mutation	ENST00000234798.4:c.795C>G	ENSP00000234798.4:p.Ile265Met	0.55555555
P6-Organoid	KATNB1	16	57784820	C	T	Missense_Mutation	ENST00000379661.3:c.371C>T	ENSP00000368982.3:p.Ser124Phe	0.10967741
P6-Organoid	BCMO1	16	81319232	C	A	Missense_Mutation	ENST00000425577.2:c.1088C>A	ENSP00000400586.2:p.Pro363Gln	0.05882352
P6-Organoid	SLC2A4	17	7186645	G	T	Missense_Mutation	ENST00000571308.1:c.115G>T	ENSP00000459864.1:p.Gly39Trp	0.04
P6-Organoid	TP53	17	7578406	C	T	Missense_Mutation	ENST00000455263.2:c.524G>A	ENSP00000398846.2:p.Arg175His	1
P6-Organoid	CCDC43	17	42766975	CTGCAGGATACCCA	C	Frame_Shift_Del	ENST00000588210.1:c.134_146del	ENSP00000467630.1:p.Leu45TrpfsTer46	0.36734693
P6-Organoid	NPEPPS	17	45663749	G	A	Missense_Mutation	ENST00000544660.1:c.725G>A	ENSP00000442461.1:p.Gly242Asp	0.08974359
P6-Organoid	ANKFN1	17	54559838	C	T	Missense_Mutation	ENST00000566473.2:c.2222C>T	ENSP00000454224.2:p.Thr741Ile	0.53125
P6-Organoid	MED13	17	60140634	T	C	Missense_Mutation	ENST00000397786.2:c.95A>G	ENSP00000380888.2:p.Lys32Arg	0.01578947
P6-Organoid	SMAD4	18	48591975	A	T	Missense_Mutation	ENST00000588745.1:c.850A>T	ENSP00000464901.1:p.Arg284Trp	0.98876404
P6-Organoid	RPS15	19	1440068	G	C	Missense_Mutation	ENST00000593052.1:c.161G>C	ENSP00000466010.1:p.Arg54Pro	0.24503311
P6-Organoid	SAFB	19	5650989	G	C	Missense_Mutation	ENST00000592224.1:c.1199G>C	ENSP00000464840.1:p.Gly400Ala	0.25
P6-Organoid	ZNF560	19	9578164	G	A	Missense_Mutation	ENST00000301480.4:c.1459C>T	ENSP00000301480.3:p.Arg487Cys	0.37634408
P6-Organoid	WIZ	19	15536142	G	A	Missense_Mutation	ENST00000599910.2:c.2041C>T	ENSP00000469022.1:p.Leu681Phe	0.05
P6-Organoid	MAST3	19	18249866	G	A	Missense_Mutation	ENST00000262811.6:c.2050G>A	ENSP00000262811.4:p.Glu684Lys	0.64335664
P6-Organoid	CIC	19	42794415	A	T	Missense_Mutation	ENST00000575354.2:c.1495A>T	ENSP00000458663.2:p.Ile499Phe	0.34693877
P6-Organoid	SIGLEC10	19	51920196	G	T	Missense_Mutation	ENST00000525998.1:c.430C>A	ENSP00000431444.1:p.Gln144Lys	0.136
P6-Organoid	SIGLEC14	19	52146840	C	T	Missense_Mutation	ENST00000360844.6:c.1098G>A	ENSP00000354090.5:p.Met366Ile	1
P6-Organoid	KIR3DL1	19	55329854	G	A	Missense_Mutation	ENST00000541392.1:c.155G>A	ENSP00000442355.1:p.Arg52His	0.19827586
P6-Organoid	SLC12A5	20	44669254	G	A	Splice_Site	ENST00000454036.2:c.923+1G>A		0.45049505
P6-Organoid	PI4KA	22	21067589	CC	GT	Missense_Mutation	ENST00000572273.1:c.5376_5377delinsAC	ENSP00000458238.1:p.Val1793Leu	0.04958677
P6-Organoid	MCM5	22	35806828	C	T	Missense_Mutation	ENST00000382011.5:c.715C>T	ENSP00000371441.5:p.Arg239Cys	0.65053763
P6-Organoid	KDM6A	X	44929421	GT	G	Frame_Shift_Del	ENST00000543216.1:c.2286del	ENSP00000443078.1:p.Thr763ProfsTer25	0.93181818

Somatic Copy Number Alterations

Primary Tumor

Organoid

Concordance between Primary tumor and Organoid

VAF-VAF Plot

Number of Shared Mutations between Primary tumor and organoid (All mutations)

Number of Shared Mutations between Primary tumor and organoid (Functional mutations)

Drug Responses

ID	Drug	IC50
P6	AZD2014	~ 4956
P6	AZD3759	~ 2784
P6	AZD4547	~ 24027
P6	AZD5363	~ 6.764e-015
P6	AZD6738	~ 81.24
P6	AZD9291	23.32
P6	I.BET.762	~ 4572
P6	Rapamycin..Sirolimus.	~ 167192
P6	AZD1775..MK.1775.	~ 0.004098
P6	Triptolide..PG490.	32.34
P6	Simvastatin	~ 351.4
P6	Temozolomide	~ 211120
P6	Imatinib.Mesylate..STI571.	~ 19428150
P6	Pazopanib..GW786034.	~ 4779
P6	Sunitinib.Malate	~ 73436
P6	Olaparib..AZD2281..KU0059436.	5271
P6	Regorafenib..BAY.73.4506.	~ 0.000
P6	Erlotinib	~ 1.299e-008
P6	Gefitinib	320.9
P6	Afatinib	~ 6739162
P6	OTX.015	~ 294.3
P6	BKM120..NVP.BKM120.	81739
P6	BYL719	~ 2.606e+019
P6	Cediranib..AZD2171.	21112
P6	Ceritinib.LDK378.	1037
P6	Crizotinib...PF.02341066.	~ 5390
P6	Dabrafenib	3526
P6	Dacomitinib	48.65
P6	Everolimus..RAD001.	170
P6	Ibrutinib..PCI.32765.	~ 182814509817
P6	Lapatinib	~ 71960409477
P6	LY2835219	~ 8562
P6	Brivanib..BMS.582664.	~ 0.009942
P6	Panobinostat	53.08
P6	Selumetinib..AZD6244.	~ 68.16
P6	Sorafenib	~ 0.000
P6	Trametinib	68.8
P6	Vandetanib..ZD6474.	639.4
P6	Vemurafenib	~ 85.69
P6	AZD5153	~ 4079
P6	ABT.199..GDC.0199..	~ 168.9
P6	ABT.888..Veliparib..NSC.737664.
P6	Avagacestat..BMS.708163.	~
P6	Axitinib...AG.013736.	1179
P6	Bosutinib..SKI.606.	~ 1250
P6	Cabozantinib..XL184.	~ 1.869e+031
P6	Dasatinib..BMS.354825.	~ 1.864e+022
P6	decitabine	~ 27802
P6	defactinib	~ 0.000
P6	Dovitinib..TKI258.CHIR258.	~ 4271
P6	Fluorouracil..5.Fluoracil..5.FU.	~ 4.160
P6	Foretinib..XL880.	68989
P6	Tivantinib..ARQ.197.	890.9
P6	Abraxane	~ 132.0
P6	AZD2461.olaparib.analog.	~ 5.689e+043
P6	Olaparib.	455.6
P6	Idelalisib	~ 335.2
P6	Irinotecan	~ 23710
P6	Nilotinib..AMN.107.	2655
P6	NVP.AEW541	~ 32880
P6	Oxaliplatin	8.56
P6	PLX3397	~
P6	Quizartinib..AC220.	~ 4.576
P6	Saracatinib..AZD0530.	1736
P6	Semagacestat..LY450139.	~ 0.000
P6	TGX.221	~ 162.8
P6	tozasertib	~ 4.758e-031
P6	Vorinostat..SAHA..MK0683.	5660
P6	XAV939	~ 3.997e+014
P6	gemcitabine	~ 2.185e+016
P6	palbociclib	~ 146955277873
P6	Neratinib..HKI.272.	~ 378.6