Organoidomics

Please contact Prof. Semin Lee, Jinho Jang or Web-master for any inquires.

3D Organoids

RAMP

Clinical Information

ID	Diagnosis	Stage	Age	BMI	Sex	CA19-9
P5	PDAC & Lung Cancer (lung NED, PDAC with peritoneal seeding)	4	67	28.3	Male	2.64

Mutation Profiles

Primary Tumor

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P5-Tissue	CSMD2	1	34011696	G	A	Missense_Mutation	ENST00000373381.4:c.9041C>T	ENSP00000362479.4:p.Ser2870Leu	0.05747126
P5-Tissue	KCNA2	1	111146840	G	A	Missense_Mutation	ENST00000485317.1:c.565C>T	ENSP00000433109.1:p.Arg189Trp	0.04313725
P5-Tissue	KCNS3	2	18112885	G	A	Missense_Mutation	ENST00000403915.1:c.610G>A	ENSP00000385968.1:p.Val204Ile	0.01273885
P5-Tissue	PCDHA9	5	140230122	G	A	Missense_Mutation	ENST00000532602.1:c.2042G>A	ENSP00000436042.1:p.Arg681Gln	0.02321083
P5-Tissue	PLXNA4	7	131866930	C	T	Missense_Mutation	ENST00000359827.3:c.3178G>A	ENSP00000352882.3:p.Val1060Ile	0.04545454
P5-Tissue	FOXD4	9	117371	C	G	Missense_Mutation	ENST00000382500.2:c.749G>C	ENSP00000371940.2:p.Gly250Ala	0.15116279
P5-Tissue	COL27A1	9	116930880	C	T	Missense_Mutation	ENST00000356083.3:c.1045C>T	ENSP00000348385.3:p.Arg349Cys	0.02227171
P5-Tissue	GOLGA2	9	131023841	C	T	Splice_Site	ENST00000609374.1:c.1108-1G>A		0.04460966
P5-Tissue	ARHGAP22	10	49687765	G	A	Missense_Mutation	ENST00000435790.2:c.383C>T	ENSP00000416701.2:p.Ala128Val	0.05607476
P5-Tissue	CACNB3	12	49221471	C	T	Missense_Mutation	ENST00000547392.1:c.1163C>T	ENSP00000446529.1:p.Thr388Ile	0.01957831
P5-Tissue	GRASP	12	52404706	G	A	Missense_Mutation	ENST00000293662.4:c.338G>A	ENSP00000293662.4:p.Gly113Asp	0.01793722
P5-Tissue	TPTE2	13	20067011	A	C	Missense_Mutation	ENST00000457266.2:c.98T>G	ENSP00000442218.1:p.Leu33Arg	0.34375
P5-Tissue	ZNF646	16	31092620	G	A	Missense_Mutation	ENST00000394979.2:c.4975G>A	ENSP00000378429.2:p.Ala1659Thr	0.04471544
P5-Tissue	ESRP2	16	68266492	A	T	Missense_Mutation	ENST00000565858.1:c.839T>A	ENSP00000454554.1:p.Leu280His	0.02312138
P5-Tissue	TP53	17	7578406	C	T	Missense_Mutation	ENST00000455263.2:c.524G>A	ENSP00000398846.2:p.Arg175His	0.02564102
P5-Tissue	SPPL2C	17	43924263	C	T	Missense_Mutation	ENST00000329196.5:c.1991C>T	ENSP00000332488.5:p.Ala664Val	0.02935420
P5-Tissue	RP4-576H24.4	20	1559023	CCA	C	Frame_Shift_Del	ENST00000564763.1:c.392_393del	ENSP00000457944.1:p.Val131GlyfsTer3	0.03384615
P5-Tissue	KIAA1755	20	36869597	C	A	Missense_Mutation	ENST00000279024.4:c.936G>T	ENSP00000279024.4:p.Lys312Asn	0.04395604
P5-Tissue	KRTAP13-3	21	31797791	C	A	Missense_Mutation	ENST00000390690.2:c.440G>T	ENSP00000375109.2:p.Cys147Phe	0.03448275
P5-Tissue	KRTAP10-6	21	46011978	A	T	Missense_Mutation	ENST00000400368.1:c.388T>A	ENSP00000383219.1:p.Cys130Ser	0.04065040
P5-Tissue	FRMPD4	X	12736390	C	T	Missense_Mutation	ENST00000380682.1:c.3445C>T	ENSP00000370057.1:p.Arg1149Cys	0.06111111
P5-Tissue	ZXDB	X	57618621	T	C	Missense_Mutation	ENST00000374888.1:c.140T>C	ENSP00000364023.1:p.Leu47Pro	0.15

Organoid

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P5-Organoid	CSMD2	1	34011696	G	A	Missense_Mutation	ENST00000373381.4:c.9041C>T	ENSP00000362479.4:p.Ser2870Leu	0.19463087
P5-Organoid	COL8A2	1	36563720	G	A	Missense_Mutation	ENST00000481785.1:c.1367C>T	ENSP00000436433.1:NA	0.13259668
P5-Organoid	RIMS3	1	41094559	T	A	Missense_Mutation	ENST00000372684.3:c.637A>T	ENSP00000361769.3:NA	0.15533980
P5-Organoid	KCNA2	1	111146840	G	A	Missense_Mutation	ENST00000485317.1:c.565C>T	ENSP00000433109.1:p.Arg189Trp	0.23880597
P5-Organoid	DENND2C	1	115168468	A	T	Missense_Mutation	ENST00000393277.1:c.138T>A	ENSP00000376958.1:NA	0.05633802
P5-Organoid	LINGO4	1	151774193	C	A	Missense_Mutation	ENST00000368820.3:c.988G>T	ENSP00000357810.3:p.Asp330Tyr	0.02325581
P5-Organoid	BCAN	1	156617855	A	G	Missense_Mutation	ENST00000361588.5:c.722A>G	ENSP00000354925.5:p.Asp241Gly	0.04794520
P5-Organoid	BRINP3	1	190067654	TC	T	Frame_Shift_Del	ENST00000534846.1:c.1488del	ENSP00000438022.1:p.Thr497LeufsTer14	0.04310344
P5-Organoid	KCNK2	1	215179287	G	T	Missense_Mutation	ENST00000391895.2:c.23G>T	ENSP00000375765.2:p.Arg8Met	0.07692307
P5-Organoid	KCNS3	2	18112885	G	A	Missense_Mutation	ENST00000403915.1:c.610G>A	ENSP00000385968.1:p.Val204Ile	0.07209302
P5-Organoid	KCNS3	2	18112957	G	A	Missense_Mutation	ENST00000403915.1:c.682G>A	ENSP00000385968.1:p.Ala228Thr	0.02898550
P5-Organoid	DPYSL5	2	27157527	C	T	Missense_Mutation	ENST00000401478.1:c.872C>T	ENSP00000385549.1:p.Ala291Val	0.08130081
P5-Organoid	GPR45	2	105858853	C	T	Missense_Mutation	ENST00000258456.1:c.538C>T	ENSP00000258456.1:p.Pro180Ser	0.05483871
P5-Organoid	CCDC174	3	14709664	G	A	Missense_Mutation	ENST00000383794.3:c.928G>A	ENSP00000373304.3:p.Gly310Ser	0.16666666
P5-Organoid	TNNC1	3	52485854	C	T	Missense_Mutation	ENST00000232975.3:c.223G>A	ENSP00000232975.3:p.Asp75Asn	0.3
P5-Organoid	PDZRN3	3	73433783	C	T	Missense_Mutation	ENST00000535920.1:c.1100G>A	ENSP00000442026.1:p.Arg367His	0.04676259
P5-Organoid	MAATS1	3	119445155	G	A	Missense_Mutation	ENST00000273390.5:c.820G>A	ENSP00000273390.5:p.Glu274Lys	0.12371134
P5-Organoid	ALDH1L1	3	125854502	T	C	Missense_Mutation	ENST00000472186.1:c.1348A>G	ENSP00000420293.1:p.Ile450Val	0.06698564
P5-Organoid	IFT80	3	160025475	G	A	Missense_Mutation	ENST00000496589.1:c.641C>T	ENSP00000420646.1:p.Thr214Met	0.10526315
P5-Organoid	KCTD8	4	44177010	G	A	Missense_Mutation	ENST00000360029.3:c.1219C>T	ENSP00000353129.3:p.Arg407Cys	0.08947368
P5-Organoid	FRYL	4	48608515	T	A	Missense_Mutation	ENST00000537810.1:c.681A>T	ENSP00000441114.1:p.Lys227Asn	0.10084033
P5-Organoid	HSD17B4	5	118832319	C	T	Missense_Mutation	ENST00000515320.1:c.896C>T	ENSP00000424613.1:p.Thr299Met	0.08860759
P5-Organoid	LOX	5	121413238	G	A	Missense_Mutation	ENST00000231004.4:c.443C>T	ENSP00000231004.4:p.Pro148Leu	0.03030303
P5-Organoid	MZB1	5	138723794	A	C	Missense_Mutation	ENST00000412103.2:c.53T>G	ENSP00000414565.2:p.Val18Gly	0.08450704
P5-Organoid	PCDHA9	5	140230122	G	A	Missense_Mutation	ENST00000532602.1:c.2042G>A	ENSP00000436042.1:p.Arg681Gln	0.27568922
P5-Organoid	PCDHB8	5	140558171	C	T	Missense_Mutation	ENST00000239444.2:c.556C>T	ENSP00000239444.2:p.Arg186Cys	0.11065573
P5-Organoid	DSP	6	7584376	C	A	Missense_Mutation	ENST00000418664.2:c.5084C>A	ENSP00000396591.2:p.Ala1695Asp	0.04
P5-Organoid	RGS17	6	153365078	T	G	Missense_Mutation	ENST00000367225.2:c.76A>C	ENSP00000356194.1:p.Asn26His	0.20588235
P5-Organoid	SMOC2	6	168999654	C	T	Missense_Mutation	ENST00000356284.2:c.794C>T	ENSP00000348630.2:p.Thr265Met	0.07874015
P5-Organoid	SNX13	7	17841230	G	A	Missense_Mutation	ENST00000428135.3:c.2279C>T	ENSP00000398789.2:p.Ser760Leu	0.10588235
P5-Organoid	HECW1	7	43484504	C	T	Missense_Mutation	ENST00000453890.1:c.1733C>T	ENSP00000407774.1:p.Ala578Val	0.09138381
P5-Organoid	SPDYE1	7	44046934	G	A	Missense_Mutation	ENST00000258704.3:c.700G>A	ENSP00000258704.3:p.Gly234Arg	0.04966887
P5-Organoid	SMURF1	7	98648560	G	T	Missense_Mutation	ENST00000361125.1:c.862C>A	ENSP00000354621.1:p.Gln288Lys	0.16981132
P5-Organoid	TMEM168	7	112424237	G	GA	Frame_Shift_Ins	ENST00000454074.1:c.643dup	ENSP00000390696.1:p.Ser215PhefsTer22	0.125
P5-Organoid	PLXNA4	7	131866930	C	T	Missense_Mutation	ENST00000359827.3:c.3178G>A	ENSP00000352882.3:p.Val1060Ile	0.17037037
P5-Organoid	TRBC2	7	142498959	G	A	Missense_Mutation	ENST00000466254.1:c.235G>A	ENSP00000417300.1:p.Arg79His	0.1121673
P5-Organoid	KAT6A	8	41844990	G	T	Missense_Mutation	ENST00000485568.1:c.692C>A	ENSP00000430606.1:p.Ala231Asp	0.12
P5-Organoid	AARD	8	117950501	C	T	Missense_Mutation	ENST00000378279.3:c.19C>T	ENSP00000367528.3:p.Arg7Cys	0.1
P5-Organoid	FAM135B	8	139163572	T	C	Missense_Mutation	ENST00000395297.1:c.3146A>G	ENSP00000378710.1:p.Lys1049Arg	0.09890109
P5-Organoid	ARID3C	9	34623622	C	T	Missense_Mutation	ENST00000378909.2:c.665G>A	ENSP00000368189.2:p.Arg222His	0.24880382
P5-Organoid	C9orf129	9	96097804	C	T	Missense_Mutation	ENST00000375419.1:c.217G>A	ENSP00000364568.1:p.Glu73Lys	0.02643171
P5-Organoid	COL27A1	9	116930880	C	T	Missense_Mutation	ENST00000356083.3:c.1045C>T	ENSP00000348385.3:p.Arg349Cys	0.21568627
P5-Organoid	GOLGA2	9	131023841	C	T	Splice_Site	ENST00000609374.1:c.1108-1G>A		0.27160493
P5-Organoid	PRRC2B	9	134330507	G	T	Missense_Mutation	ENST00000458550.1:c.1165G>T	ENSP00000398853.1:p.Asp389Tyr	0.26168224
P5-Organoid	SVIL	10	29811448	C	A	Nonsense_Mutation	ENST00000375400.3:c.2002G>T	ENSP00000364549.3:p.Glu668Ter	0.06989247
P5-Organoid	ARHGAP22	10	49687765	G	A	Missense_Mutation	ENST00000435790.2:c.383C>T	ENSP00000416701.2:p.Ala128Val	0.15702479
P5-Organoid	ZNF503	10	77159052	ATCCGGACTTCAGCG	A	Frame_Shift_Del	ENST00000535216.1:c.1382_1395del	ENSP00000438988.1:p.Ala461ValfsTer44	0.07983193
P5-Organoid	GLUD1	10	88834343	C	A	Missense_Mutation	ENST00000544149.1:c.212G>T	ENSP00000444732.1:p.Arg71Met	0.125
P5-Organoid	SORCS3	10	107005354	G	C	Missense_Mutation	ENST00000369701.3:c.2923G>C	ENSP00000358715.3:p.Asp975His	0.16379310
P5-Organoid	VWA2	10	116048814	T	C	Missense_Mutation	ENST00000603594.1:c.1688T>C	ENSP00000473752.1:p.Val563Ala	0.11650485
P5-Organoid	DCHS1	11	6661869	G	A	Missense_Mutation	ENST00000299441.3:c.976C>T	ENSP00000299441.3:p.Arg326Trp	0.12977099
P5-Organoid	CCDC73	11	32657248	C	G	Missense_Mutation	ENST00000335185.5:c.1179G>C	ENSP00000335325.5:p.Lys393Asn	0.13333333
P5-Organoid	KIAA1549L	11	33581396	C	A	Missense_Mutation	ENST00000389726.3:c.3084C>A	ENSP00000374376.3:p.Ser1028Arg	0.14942528
P5-Organoid	TTC12	11	113211403	T	A	Missense_Mutation	ENST00000529221.1:c.844T>A	ENSP00000433757.1:p.Phe282Ile	0.02580645
P5-Organoid	HTR3B	11	113802589	T	A	Missense_Mutation	ENST00000537778.1:c.335T>A	ENSP00000443118.1:p.Phe112Tyr	0.06161137
P5-Organoid	SLC6A12	12	304450	C	T	Missense_Mutation	ENST00000536824.1:c.1370G>A	ENSP00000444268.1:p.Ser457Asn	0.05113636
P5-Organoid	KRAS	12	25398284	C	T	Missense_Mutation	ENST00000557334.1:c.35G>A	ENSP00000452512.1:p.Gly12Asp	0.21052631
P5-Organoid	CACNB3	12	49221471	C	T	Missense_Mutation	ENST00000547392.1:c.1163C>T	ENSP00000446529.1:p.Thr388Ile	0.13863216
P5-Organoid	GRASP	12	52404706	G	A	Missense_Mutation	ENST00000293662.4:c.338G>A	ENSP00000293662.4:p.Gly113Asp	0.23152709
P5-Organoid	SLC17A8	12	100774715	G	A	Missense_Mutation	ENST00000392989.3:c.338G>A	ENSP00000376715.3:p.Gly113Glu	0.14814814
P5-Organoid	ACADS	12	121176633	C	T	Missense_Mutation	ENST00000411593.2:c.932C>T	ENSP00000401045.2:p.Ala311Val	0.03825136
P5-Organoid	SLC15A4	12	129285547	CA	C	Frame_Shift_Del	ENST00000544112.1:c.254del	ENSP00000439946.1:p.Leu85TrpfsTer6	0.26050420
P5-Organoid	TOX4	14	21960767	CAA	C	Frame_Shift_Del	ENST00000448790.2:c.924_925del	ENSP00000393080.2:p.Ile309ArgfsTer12	0.04938271
P5-Organoid	TOX4	14	21960770	T	C	Missense_Mutation	ENST00000448790.2:c.926T>C	ENSP00000393080.2:p.Ile309Thr	0.04938271
P5-Organoid	OXA1L	14	23236470	C	T	Missense_Mutation	ENST00000604262.1:c.77C>T	ENSP00000474623.1:p.Ala26Val	0.04562737
P5-Organoid	AKAP6	14	33004853	G	A	Missense_Mutation	ENST00000557354.1:c.418G>A	ENSP00000450531.1:p.Val140Met	0.06811145
P5-Organoid	AHNAK2	14	105411396	C	G	Missense_Mutation	ENST00000333244.5:c.10392G>C	ENSP00000353114.4:p.Lys3464Asn	0.19125683
P5-Organoid	SNURF	15	25207326	G	C	Missense_Mutation	ENST00000577949.1:c.80G>C	ENSP00000463201.1:p.Arg27Pro	0.10526315
P5-Organoid	USP8	15	50754515	G	GAA	Frame_Shift_Ins	ENST00000433963.1:c.539_540dup	ENSP00000405537.1:p.Gly181LysfsTer12	0.10526315
P5-Organoid	AKAP13	15	86198910	C	T	Missense_Mutation	ENST00000394518.2:c.4637C>T	ENSP00000378026.2:p.Ala1546Val	0.07547169
P5-Organoid	GLYR1	16	4882093	C	G	Missense_Mutation	ENST00000591451.1:c.424G>C	ENSP00000468328.1:p.Glu142Gln	0.07359307
P5-Organoid	SLC5A11	16	24881226	G	T	Missense_Mutation	ENST00000569071.1:c.20G>T	ENSP00000456376.1:p.Gly7Val	0.05882352
P5-Organoid	ESRP2	16	68266492	A	T	Missense_Mutation	ENST00000565858.1:c.839T>A	ENSP00000454554.1:p.Leu280His	0.12842105
P5-Organoid	FUK	16	70507098	C	T	Missense_Mutation	ENST00000571514.1:c.98C>T	ENSP00000462584.1:p.Ala33Val	0.23140495
P5-Organoid	PKD1L2	16	81167189	C	A	Missense_Mutation	ENST00000533478.1:c.3781G>T	ENSP00000434644.1:p.Ala1261Ser	0.12568306
P5-Organoid	POLR2A	17	7414827	G	A	Missense_Mutation	ENST00000322644.6:c.4021G>A	ENSP00000314949.6:p.Val1341Met	0.08717948
P5-Organoid	TP53	17	7578406	C	T	Missense_Mutation	ENST00000455263.2:c.524G>A	ENSP00000398846.2:p.Arg175His	0.375
P5-Organoid	CYB5D1	17	7762829	ATCCGG	A	Frame_Shift_Del	ENST00000570446.1:c.203_207del	ENSP00000461852.1:p.Ile68ArgfsTer2	0.07017543
P5-Organoid	CCDC42	17	8647882	G	A	Missense_Mutation	ENST00000539522.2:c.46C>T	ENSP00000444359.2:p.Arg16Trp	0.05633802
P5-Organoid	DNAH9	17	11684458	C	T	Missense_Mutation	ENST00000454412.2:c.7685C>T	ENSP00000414874.2:p.Thr2562Ile	0.07894736
P5-Organoid	SPPL2C	17	43924263	C	T	Missense_Mutation	ENST00000329196.5:c.1991C>T	ENSP00000332488.5:p.Ala664Val	0.22704081
P5-Organoid	SDK2	17	71344846	G	T	Missense_Mutation	ENST00000392650.3:c.6057C>A	ENSP00000376421.3:p.Ser2019Arg	0.29931972
P5-Organoid	CBLN2	18	70205952	G	T	Missense_Mutation	ENST00000585159.1:c.413C>A	ENSP00000463771.1:p.Pro138Gln	0.12612612
P5-Organoid	ZFR2	19	3827531	C	T	Missense_Mutation	ENST00000262961.4:c.973G>A	ENSP00000262961.3:p.Ala325Thr	0.05882352
P5-Organoid	ZNF625	19	12256195	C	T	Missense_Mutation	ENST00000542938.1:c.838G>A	ENSP00000438436.1:p.Val280Ile	0.05479452
P5-Organoid	EXOSC5	19	41897867	C	T	Missense_Mutation	ENST00000596905.1:c.149G>A	ENSP00000471002.1:p.Gly50Asp	0.085
P5-Organoid	LILRB1	19	55147987	GA	CC	Missense_Mutation	ENST00000434867.2:c.1690_1691delinsCC	ENSP00000405243.2:p.Glu564Pro	0.13333333
P5-Organoid	NLRP5	19	56561882	C	T	Missense_Mutation	ENST00000390649.3:c.3056C>T	ENSP00000375063.3:p.Pro1019Leu	0.02
P5-Organoid	ADRA1D	20	4228688	A	G	Missense_Mutation	ENST00000379453.4:c.917T>C	ENSP00000368766.4:p.Ile306Thr	0.03143418
P5-Organoid	PROKR2	20	5282708	A	G	Missense_Mutation	ENST00000546004.1:c.1133T>C	ENSP00000440790.1:p.Val378Ala	0.03070175
P5-Organoid	JAG1	20	10629308	TC	CT	Missense_Mutation	ENST00000423891.2:c.980_981delinsAG	ENSP00000389519.2:p.Arg327Lys	0.10169491
P5-Organoid	KIAA1755	20	36869597	C	A	Missense_Mutation	ENST00000279024.4:c.936G>T	ENSP00000279024.4:p.Lys312Asn	0.19921875
P5-Organoid	ADNP	20	49508046	T	C	Missense_Mutation	ENST00000396032.3:c.3205A>G	ENSP00000379349.2:p.Ile1069Val	0.07352941
P5-Organoid	NFATC2	20	50092093	G	C	Missense_Mutation	ENST00000610033.1:c.780C>G	ENSP00000477142.1:p.Ile260Met	0.09848484
P5-Organoid	ZNF831	20	57769069	G	A	Missense_Mutation	ENST00000371030.2:c.2995G>A	ENSP00000360069.2:p.Gly999Ser	0.07291666
P5-Organoid	KRTAP13-3	21	31797791	C	A	Missense_Mutation	ENST00000390690.2:c.440G>T	ENSP00000375109.2:p.Cys147Phe	0.15107913
P5-Organoid	DOPEY2	21	37660356	G	A	Missense_Mutation	ENST00000399151.3:c.6205G>A	ENSP00000382104.3:p.Ala2069Thr	0.03809523
P5-Organoid	KRTAP10-4	21	45994110	A	G	Missense_Mutation	ENST00000400374.3:c.475A>G	ENSP00000383225.3:p.Ile159Val	0.31956912
P5-Organoid	SAMM50	22	44392219	A	G	Missense_Mutation	ENST00000396202.3:c.736A>G	ENSP00000379505.3:p.Ile246Val	0.02734375
P5-Organoid	FRMPD4	X	12736390	C	T	Missense_Mutation	ENST00000380682.1:c.3445C>T	ENSP00000370057.1:p.Arg1149Cys	0.20338983
P5-Organoid	HEPH	X	65486401	G	A	Missense_Mutation	ENST00000519389.1:c.3526G>A	ENSP00000430620.1:p.Val1176Ile	0.40540540
P5-Organoid	CXorf40B	X	149101881	A	G	Missense_Mutation	ENST00000462691.1:c.212T>C	ENSP00000417546.1:p.Leu71Ser	0.03547297

Somatic Copy Number Alterations

Primary Tumor

Organoid

Concordance between Primary tumor and Organoid

VAF-VAF Plot

Number of Shared Mutations between Primary tumor and organoid (All mutations)

Number of Shared Mutations between Primary tumor and organoid (Functional mutations)

Drug Responses

ID	Drug	IC50
P5	AZD2014	0.02116
P5	AZD3759	593.1
P5	AZD4547	~ 65033358449
P5	AZD5363	~ 199.2
P5	AZD6738	720.9
P5	AZD9291	1043
P5	I.BET.762	~ 2.084e-013
P5	Rapamycin..Sirolimus.	~ 4.172
P5	AZD1775..MK.1775.	~ 273.6
P5	Triptolide..PG490.	7.575
P5	Simvastatin	~ 7.557e+030
P5	Temozolomide	~ 31.00
P5	Imatinib.Mesylate..STI571.	~ 5116
P5	Pazopanib..GW786034.	~ 25211349
P5	Sunitinib.Malate	~ 5075
P5	Olaparib..AZD2281..KU0059436.	1.312E+16
P5	Regorafenib..BAY.73.4506.	~ 2.040e-008
P5	Erlotinib	14835
P5	Gefitinib	~ 1.745e-015
P5	Afatinib	~ 1.580e+034
P5	OTX.015	~ 0.1004
P5	BKM120..NVP.BKM120.	~ 2714620108
P5	BYL719	2260
P5	Cediranib..AZD2171.	10248
P5	Ceritinib.LDK378.	656.5
P5	Crizotinib...PF.02341066.	~ 126310255
P5	Dabrafenib	~ 1.927e+024
P5	Dacomitinib	~ 3.095e-025
P5	Everolimus..RAD001.	92.32
P5	Ibrutinib..PCI.32765.	~ 299501
P5	Lapatinib	4428
P5	LY2835219	1554
P5	Brivanib..BMS.582664.	~ 234000
P5	Panobinostat	24.86
P5	Selumetinib..AZD6244.	1540
P5	Sorafenib	~ 0.004153
P5	Trametinib	5.83
P5	Vandetanib..ZD6474.	1489
P5	Vemurafenib	~ 19976
P5	AZD5153	178.5
P5	ABT.199..GDC.0199..	~ 2.611
P5	ABT.888..Veliparib..NSC.737664.	~ 12.60
P5	Avagacestat..BMS.708163.	~ 101.3
P5	Axitinib...AG.013736.	~ 4.313e-015
P5	Bosutinib..SKI.606.	737.9
P5	Cabozantinib..XL184.	~ 1.730e+015
P5	Dasatinib..BMS.354825.	~ 7.949e-009
P5	decitabine	~ 2.476e-015
P5	defactinib	~ 1295
P5	Dovitinib..TKI258.CHIR258.	1850
P5	Fluorouracil..5.Fluoracil..5.FU.	~ 4881
P5	Foretinib..XL880.	515.1
P5	Tivantinib..ARQ.197.	28.92
P5	Abraxane	~ 0.01456
P5	AZD2461.olaparib.analog.	37.14
P5	Olaparib.	~ 0.07561
P5	Idelalisib	~ 23376
P5	Irinotecan	~ 4330
P5	Nilotinib..AMN.107.	~ 579164
P5	NVP.AEW541	3346
P5	Oxaliplatin	~ 4648
P5	PLX3397	~ 254413
P5	Quizartinib..AC220.	~ 41488
P5	Saracatinib..AZD0530.	867.7
P5	Semagacestat..LY450139.	~ 0.000
P5	TGX.221	~ 5443
P5	tozasertib	~ 71.91
P5	Vorinostat..SAHA..MK0683.	790.6
P5	XAV939	~ 607.6
P5	gemcitabine	780.3
P5	palbociclib	~ 4.150e+022
P5	Neratinib..HKI.272.	1621