Organoidomics

Please contact Prof. Semin Lee, Jinho Jang or Web-master for any inquires.

3D Organoids

RAMP

Clinical Information

ID	Diagnosis	Stage	Age	BMI	Sex	CA19-9
P13	thyroid, breast, lung cancer --> PDAC	3	77	25.3	Female

Mutation Profiles

Primary Tumor

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P13-Tissue	MED18	1	28660934	T	A	Missense_Mutation	ENST00000398997.2:c.80T>A	ENSP00000381963.2:p.Val27Asp	0.23913043
P13-Tissue	SFPQ	1	35658390	CGGCTGATGCGGTGGCGGCTGCTGCGGCGGT	C	In_Frame_Del	ENST00000357214.5:c.231_260del	ENSP00000349748.5:NA	0.19819819
P13-Tissue	WDR63	1	85589904	G	A	Nonsense_Mutation	ENST00000370596.1:c.1965G>A	ENSP00000359628.1:p.Trp694Ter	0.20526315
P13-Tissue	ZNF644	1	91406264	C	T	Missense_Mutation	ENST00000370440.1:c.647G>A	ENSP00000359469.1:p.Gly216Asp	0.205
P13-Tissue	QSOX1	1	180151445	G	A	Missense_Mutation	ENST00000367602.3:c.743G>A	ENSP00000356574.3:p.Arg248Gln	0.06206896
P13-Tissue	FAM129A	1	184777360	G	A	Missense_Mutation	ENST00000367511.3:c.1183C>T	ENSP00000356481.3:p.Arg395Trp	0.18888888
P13-Tissue	NAV1	1	201779742	C	G	Missense_Mutation	ENST00000367302.1:c.4512C>G	ENSP00000356271.1:p.His1551Gln	0.16207951
P13-Tissue	KLHL12	1	202864790	T	C	Missense_Mutation	ENST00000435533.3:c.1109A>G	ENSP00000416886.3:p.Tyr332Cys	0.39655172
P13-Tissue	LAMB3	1	209805986	T	C	Missense_Mutation	ENST00000391911.1:c.764A>G	ENSP00000375778.1:p.His255Arg	0.08620689
P13-Tissue	TPO	2	1544469	C	T	Missense_Mutation	ENST00000382201.3:c.2551C>T	ENSP00000371636.3:p.Arg851Trp	0.12337662
P13-Tissue	ADAM17	2	9676024	T	C	Missense_Mutation	ENST00000497134.1:c.389A>G	ENSP00000418728.1:p.His130Arg	0.22058823
P13-Tissue	CYP1B1	2	38301868	G	A	Missense_Mutation	ENST00000407341.1:c.664C>T	ENSP00000384972.1:p.Arg222Cys	0.14285714
P13-Tissue	TBC1D8	2	101638901	T	C	Missense_Mutation	ENST00000409318.1:c.2603A>G	ENSP00000386856.1:p.Gln868Arg	0.18232044
P13-Tissue	TTN	2	179436299	T	C	Missense_Mutation	ENST00000591111.1:c.69637A>G	ENSP00000465570.1:p.Thr23213Ala	0.12162162
P13-Tissue	ERBB4	2	212576801	C	A	Missense_Mutation	ENST00000436443.1:c.1098G>T	ENSP00000403204.1:p.Leu366Phe	0.10588235
P13-Tissue	UBE2F	2	238881831	C	T	Missense_Mutation	ENST00000414443.1:c.82C>T	ENSP00000399183.1:p.Arg28Trp	0.12820512
P13-Tissue	CD200	3	112066477	G	A	Missense_Mutation	ENST00000473539.1:c.569G>A	ENSP00000420298.1:p.Arg190His	0.17834394
P13-Tissue	HSPBAP1	3	122459309	TG	GA	Missense_Mutation	ENST00000306103.2:c.1349_1350delinsTC	ENSP00000302562.2:p.Ser450Phe	0.21134020
P13-Tissue	AADACL2	3	151463436	G	A	Missense_Mutation	ENST00000356517.3:c.571G>A	ENSP00000348911.3:p.Gly191Arg	0.15662650
P13-Tissue	PHOX2B	4	41748278	G	A	Missense_Mutation	ENST00000226382.2:c.491C>T	ENSP00000226382.2:p.Ala164Val	0.19834710
P13-Tissue	NPNT	4	106863805	A	G	Missense_Mutation	ENST00000514622.1:c.1105A>G	ENSP00000422044.1:p.Thr369Ala	0.22142857
P13-Tissue	BBS12	4	123665161	C	A	Missense_Mutation	ENST00000542236.1:c.2114C>A	ENSP00000438273.1:p.Thr705Lys	0.22448979
P13-Tissue	FBN2	5	127680139	C	T	Missense_Mutation	ENST00000508989.1:c.3182G>A	ENSP00000425596.1:p.Gly1061Glu	0.14
P13-Tissue	PCDHA13	5	140263387	G	A	Missense_Mutation	ENST00000409494.1:c.1534G>A	ENSP00000386821.1:p.Ala512Thr	0.09285714
P13-Tissue	HDAC3	5	141009288	C	A	Missense_Mutation	ENST00000305264.3:c.439G>T	ENSP00000302967.3:p.Val147Phe	0.08771929
P13-Tissue	PTCHD4	6	48036118	A	G	Missense_Mutation	ENST00000543600.1:c.223T>C	ENSP00000439864.1:p.Phe75Leu	0.35658914
P13-Tissue	FYN	6	112035550	G	A	Missense_Mutation	ENST00000538466.1:c.344C>T	ENSP00000440646.1:p.Ser115Leu	0.33333333
P13-Tissue	COL28A1	7	7559696	G	C	Missense_Mutation	ENST00000399429.3:c.810C>G	ENSP00000382356.3:p.Asn270Lys	0.09638554
P13-Tissue	SEMA3C	7	80447625	C	T	Missense_Mutation	ENST00000544525.1:c.491G>A	ENSP00000445649.1:p.Arg164Lys	0.22651933
P13-Tissue	PCLO	7	82785624	A	C	Missense_Mutation	ENST00000423517.2:c.333T>G	ENSP00000388393.2:p.Ser111Arg	0.25954198
P13-Tissue	TNPO3	7	128615916	C	A	Missense_Mutation	ENST00000482320.1:c.1937G>T	ENSP00000420089.1:p.Gly646Val	0.18072289
P13-Tissue	TNPO3	7	128640524	G	T	Missense_Mutation	ENST00000482320.1:c.772C>A	ENSP00000420089.1:p.Leu258Met	0.24742268
P13-Tissue	PTN	7	136938319	C	G	Missense_Mutation	ENST00000393083.2:c.181G>C	ENSP00000376798.2:p.Asp61His	0.11450381
P13-Tissue	KIAA1549	7	138603203	G	T	Missense_Mutation	ENST00000440172.1:c.1169C>A	ENSP00000406661.1:p.Thr390Lys	0.23841059
P13-Tissue	DLC1	8	12952690	C	T	Missense_Mutation	ENST00000520226.1:c.1699G>A	ENSP00000428028.1:p.Val567Ile	0.14473684
P13-Tissue	C8orf46	8	67417623	C	T	Missense_Mutation	ENST00000522977.1:c.140C>T	ENSP00000430141.1:p.Ser47Leu	0.08
P13-Tissue	DMRT2	9	1056740	G	A	Missense_Mutation	ENST00000382251.3:c.1153G>A	ENSP00000371686.3:p.Asp385Asn	0.24074074
P13-Tissue	CDKN2A	9	21971192	T	TC	Frame_Shift_Ins	ENST00000579755.1:c.208_209insG	ENSP00000462950.1:p.Gln70ArgfsTer91	0.33884297
P13-Tissue	CDKN2A	9	21971193	G	C	Missense_Mutation	ENST00000579755.1:c.208C>G	ENSP00000462950.1:p.Gln70Glu	0.41739130
P13-Tissue	TMEM245	9	111881989	C	T	Missense_Mutation	ENST00000374586.3:c.205G>A	ENSP00000363714.3:p.Ala69Thr	0.14473684
P13-Tissue	RSU1	10	16794646	G	C	Missense_Mutation	ENST00000602389.1:c.331C>G	ENSP00000473588.1:p.Leu111Val	0.04424778
P13-Tissue	OR56A4	11	6023895	A	C	Missense_Mutation	ENST00000330728.4:c.484T>G	ENSP00000328215.4:p.Phe162Val	0.15668202
P13-Tissue	SYT9	11	7273496	C	A	Missense_Mutation	ENST00000318881.6:c.79C>A	ENSP00000324419.6:p.His27Asn	0.20422535
P13-Tissue	KRAS	12	25398284	C	A	Missense_Mutation	ENST00000557334.1:c.35G>T	ENSP00000452512.1:p.Gly12Val	0.38410596
P13-Tissue	LIMA1	12	50571137	T	C	Missense_Mutation	ENST00000552909.1:c.1507A>G	ENSP00000450087.1:p.Lys503Glu	0.23178807
P13-Tissue	KRT86	12	52702226	C	A	Missense_Mutation	ENST00000544024.1:c.1318C>A	ENSP00000443169.1:p.Leu440Ile	0.28742515
P13-Tissue	BTBD11	12	108043007	G	A	Missense_Mutation	ENST00000494235.2:c.184G>A	ENSP00000448322.1:p.Gly62Ser	0.15294117
P13-Tissue	ATXN2	12	111895054	T	A	Missense_Mutation	ENST00000608853.1:c.3000A>T	ENSP00000476504.1:p.Gln1000His	0.19469026
P13-Tissue	OR4Q3	14	20215980	C	T	Missense_Mutation	ENST00000331723.1:c.394C>T	ENSP00000330049.1:p.Arg132Cys	0.10101010
P13-Tissue	ZFYVE26	14	68219074	C	T	Missense_Mutation	ENST00000557306.1:c.896G>A	ENSP00000452142.1:p.Arg299Lys	0.24657534
P13-Tissue	PLD4	14	105397232	C	T	Missense_Mutation	ENST00000540372.1:c.892C>T	ENSP00000438677.1:p.Pro298Ser	0.27333333
P13-Tissue	OR4M2	15	22369288	C	T	Missense_Mutation	ENST00000332663.2:c.713C>T	ENSP00000329467.2:p.Ala238Val	0.15789473
P13-Tissue	OCA2	15	28259938	G	A	Missense_Mutation	ENST00000382996.2:c.1028C>T	ENSP00000372457.2:p.Ala343Val	0.18686868
P13-Tissue	CYP19A1	15	51529188	C	T	Missense_Mutation	ENST00000559878.1:c.164G>A	ENSP00000453149.1:p.Gly55Glu	0.11971831
P13-Tissue	GOLGA6B	15	72953677	G	A	Missense_Mutation	ENST00000421285.3:c.637G>A	ENSP00000408132.3:p.Ala213Thr	0.14285714
P13-Tissue	AGBL1	15	86838559	C	T	Missense_Mutation	ENST00000441037.2:c.2156C>T	ENSP00000413001.2:p.Thr719Met	0.29032258
P13-Tissue	SULT1A1	16	28618125	C	T	Missense_Mutation	ENST00000569554.1:c.551G>A	ENSP00000457912.1:p.Arg184His	0.04376367
P13-Tissue	TP53	17	7578416	C	A	Missense_Mutation	ENST00000455263.2:c.514G>T	ENSP00000398846.2:p.Val172Phe	0.36440678
P13-Tissue	MYH10	17	8455444	C	T	Missense_Mutation	ENST00000396239.1:c.809G>A	ENSP00000379539.1:p.Arg270His	0.30487804
P13-Tissue	TBC1D3	17	36339584	G	T	Missense_Mutation	ENST00000537432.1:c.1073C>A	ENSP00000439621.1:p.Pro358Gln	0.06666666
P13-Tissue	KRT10	17	38975196	C	T	Missense_Mutation	ENST00000269576.5:c.1591G>A	ENSP00000269576.5:p.Gly531Ser	0.15384615
P13-Tissue	IGF2BP1	17	47075230	C	A	Missense_Mutation	ENST00000431824.2:c.123C>A	ENSP00000389135.2:p.Phe41Leu	0.04123711
P13-Tissue	HN1	17	73143740	A	C	Missense_Mutation	ENST00000581874.1:c.208T>G	ENSP00000462805.1:p.Ser70Ala	0.24137931
P13-Tissue	CSNK1D	17	80213406	C	T	Missense_Mutation	ENST00000398519.5:c.235G>A	ENSP00000381531.5:p.Val79Ile	0.21465968
P13-Tissue	SMAD4	18	48584569	C	T	Nonsense_Mutation	ENST00000398417.2:c.742C>T	ENSP00000381452.1:p.Gln248Ter	0.14814814
P13-Tissue	ZNF223	19	44570549	G	A	Missense_Mutation	ENST00000434772.3:c.568G>A	ENSP00000401947.1:p.Ala190Thr	0.19285714
P13-Tissue	OSCAR	19	54599099	TGGGGCGGAGGAGGC	T	Frame_Shift_Del	ENST00000391761.1:c.646_659del	ENSP00000375641.1:p.Ala216ArgfsTer112	0.20895522
P13-Tissue	LILRB5	19	54758272	G	A	Missense_Mutation	ENST00000450632.1:c.1235C>T	ENSP00000414225.1:p.Ser412Phe	0.16483516
P13-Tissue	CNBD2	20	34571918	G	A	Missense_Mutation	ENST00000538900.1:c.422G>A	ENSP00000442729.1:p.Arg141His	0.26923076
P13-Tissue	TSHZ2	20	51872044	G	A	Missense_Mutation	ENST00000603338.2:c.2038G>A	ENSP00000475114.1:p.Ala680Thr	0.27796610
P13-Tissue	CELSR1	22	46807575	T	C	Missense_Mutation	ENST00000262738.3:c.4693A>G	ENSP00000262738.3:p.Thr1565Ala	0.32236842
P13-Tissue	MAOB	X	43639605	G	C	Missense_Mutation	ENST00000538942.1:c.1015C>G	ENSP00000442240.1:p.Leu339Val	0.15384615
P13-Tissue	SLC9A7	X	46541775	C	T	Missense_Mutation	ENST00000328306.4:c.521G>A	ENSP00000330320.4:p.Arg174Gln	0.28834355
P13-Tissue	CPXCR1	X	88009029	A	G	Missense_Mutation	ENST00000373111.1:c.614A>G	ENSP00000362203.1:p.Tyr205Cys	0.24731182
P13-Tissue	FAM50A	X	153677288	C	T	Missense_Mutation	ENST00000393600.3:c.634C>T	ENSP00000377225.3:p.Arg212Trp	0.05759162
P13-Tissue	F8	X	154158530	C	G	Missense_Mutation	ENST00000360256.4:c.3535G>C	ENSP00000353393.4:p.Asp1179His	0.31818181

Organoid

ID	Gene	CHROM	POS	REF	ALT	Consequence	HGVSc	HGVSp	VAF
P13-Organoid	MED18	1	28660934	T	A	Missense_Mutation	ENST00000398997.2:c.80T>A	ENSP00000381963.2:p.Val27Asp	0.11320754
P13-Organoid	SFPQ	1	35658390	CGGCTGATGCGGTGGCGGCTGCTGCGGCGGT	C	In_Frame_Del	ENST00000357214.5:c.231_260del	ENSP00000349748.5:NA	0.10215053
P13-Organoid	MROH7	1	55136204	C	T	Missense_Mutation	ENST00000545244.1:c.128C>T	ENSP00000442333.1:NA	0.24137931
P13-Organoid	WDR63	1	85589904	G	A	Nonsense_Mutation	ENST00000370596.1:c.1965G>A	ENSP00000359628.1:p.Trp694Ter	0.05147058
P13-Organoid	ZNF644	1	91406264	C	T	Missense_Mutation	ENST00000370440.1:c.647G>A	ENSP00000359469.1:p.Gly216Asp	0.09900990
P13-Organoid	FAM129A	1	184777360	G	A	Missense_Mutation	ENST00000367511.3:c.1183C>T	ENSP00000356481.3:p.Arg395Trp	0.07563025
P13-Organoid	TPR	1	186292940	G	A	Missense_Mutation	ENST00000367478.4:c.6175C>T	ENSP00000356448.3:NA	0.08571428
P13-Organoid	NAV1	1	201779742	C	G	Missense_Mutation	ENST00000367302.1:c.4512C>G	ENSP00000356271.1:p.His1551Gln	0.07092198
P13-Organoid	KDM5B	1	202725503	G	T	Missense_Mutation	ENST00000367265.3:c.1339C>A	ENSP00000356234.3:NA	0.10256410
P13-Organoid	KLHL12	1	202864790	T	C	Missense_Mutation	ENST00000435533.3:c.1109A>G	ENSP00000416886.3:p.Tyr332Cys	0.15053763
P13-Organoid	TPO	2	1544469	C	T	Missense_Mutation	ENST00000382201.3:c.2551C>T	ENSP00000371636.3:p.Arg851Trp	0.09473684
P13-Organoid	CYP1B1	2	38301868	G	A	Missense_Mutation	ENST00000407341.1:c.664C>T	ENSP00000384972.1:p.Arg222Cys	0.07865168
P13-Organoid	SMEK2	2	55844329	G	T	Nonsense_Mutation	ENST00000407823.3:c.93C>A	ENSP00000385912.3:p.Tyr31Ter	0.03896103
P13-Organoid	TBC1D8	2	101638901	T	C	Missense_Mutation	ENST00000409318.1:c.2603A>G	ENSP00000386856.1:p.Gln868Arg	0.11564625
P13-Organoid	TTN	2	179436299	T	C	Missense_Mutation	ENST00000591111.1:c.69637A>G	ENSP00000465570.1:p.Thr23213Ala	0.04838709
P13-Organoid	TTN	2	179572394	C	G	Missense_Mutation	ENST00000591111.1:c.27949G>C	ENSP00000465570.1:p.Asp9317His	0.08421052
P13-Organoid	CD200	3	112066477	G	A	Missense_Mutation	ENST00000473539.1:c.569G>A	ENSP00000420298.1:p.Arg190His	0.07692307
P13-Organoid	HSPBAP1	3	122459309	TG	GA	Missense_Mutation	ENST00000306103.2:c.1349_1350delinsTC	ENSP00000302562.2:p.Ser450Phe	0.12698412
P13-Organoid	MYLK	3	123366135	G	C	Missense_Mutation	ENST00000475616.1:c.4555C>G	ENSP00000418335.1:p.Pro1519Ala	0.19852941
P13-Organoid	AADACL2	3	151463436	G	A	Missense_Mutation	ENST00000356517.3:c.571G>A	ENSP00000348911.3:p.Gly191Arg	0.15094339
P13-Organoid	TNIK	3	170906530	AATAAC	A	Frame_Shift_Del	ENST00000538048.1:c.595_599del	ENSP00000443278.1:p.Val199CysfsTer3	0.06060606
P13-Organoid	PHOX2B	4	41748278	G	A	Missense_Mutation	ENST00000226382.2:c.491C>T	ENSP00000226382.2:p.Ala164Val	0.12698412
P13-Organoid	AMTN	4	71396888	A	G	Missense_Mutation	ENST00000504451.1:c.487A>G	ENSP00000422452.1:p.Thr163Ala	0.19811320
P13-Organoid	NPNT	4	106863805	A	G	Missense_Mutation	ENST00000514622.1:c.1105A>G	ENSP00000422044.1:p.Thr369Ala	0.09859154
P13-Organoid	BBS12	4	123665161	C	A	Missense_Mutation	ENST00000542236.1:c.2114C>A	ENSP00000438273.1:p.Thr705Lys	0.04545454
P13-Organoid	HDAC3	5	141009288	C	A	Missense_Mutation	ENST00000305264.3:c.439G>T	ENSP00000302967.3:p.Val147Phe	0.09433962
P13-Organoid	TNIP1	5	150413268	TGG	CCA	Missense_Mutation	ENST00000523338.1:c.1678_1680inv	ENSP00000428243.1:p.Pro560Trp	0.02040816
P13-Organoid	FYN	6	112035550	G	A	Missense_Mutation	ENST00000538466.1:c.344C>T	ENSP00000440646.1:p.Ser115Leu	0.10204081
P13-Organoid	BCLAF1	6	136599569	A	C	Nonsense_Mutation	ENST00000531224.1:c.450T>G	ENSP00000435210.1:p.Tyr150Ter	0.08571428
P13-Organoid	PLG	6	161139445	A	T	Missense_Mutation	ENST00000308192.9:c.907A>T	ENSP00000308938.9:p.Thr303Ser	0.16822429
P13-Organoid	SEMA3C	7	80447625	C	T	Missense_Mutation	ENST00000544525.1:c.491G>A	ENSP00000445649.1:p.Arg164Lys	0.10975609
P13-Organoid	PTN	7	136938319	C	G	Missense_Mutation	ENST00000393083.2:c.181G>C	ENSP00000376798.2:p.Asp61His	0.08181818
P13-Organoid	KIAA1549	7	138603203	G	T	Missense_Mutation	ENST00000440172.1:c.1169C>A	ENSP00000406661.1:p.Thr390Lys	0.06306306
P13-Organoid	SLC52A2	8	145584471	G	A	Missense_Mutation	ENST00000526752.1:c.139G>A	ENSP00000433796.1:p.Val47Met	0.07432432
P13-Organoid	DMRT2	9	1056740	G	A	Missense_Mutation	ENST00000382251.3:c.1153G>A	ENSP00000371686.3:p.Asp385Asn	0.06153846
P13-Organoid	CDKN2A	9	21971192	T	TC	Frame_Shift_Ins	ENST00000579755.1:c.208_209insG	ENSP00000462950.1:p.Gln70ArgfsTer91	0.11842105
P13-Organoid	CDKN2A	9	21971193	G	C	Missense_Mutation	ENST00000579755.1:c.208C>G	ENSP00000462950.1:p.Gln70Glu	0.13888888
P13-Organoid	UBQLN1	9	86293424	C	T	Missense_Mutation	ENST00000376395.4:c.802G>A	ENSP00000365576.4:p.Gly268Arg	0.06666666
P13-Organoid	CAMSAP1	9	138712980	T	C	Missense_Mutation	ENST00000409386.3:c.3560A>G	ENSP00000386420.3:p.Asn1187Ser	0.06578947
P13-Organoid	FBXW5	9	139835895	C	T	Missense_Mutation	ENST00000325285.3:c.1265G>A	ENSP00000313034.3:p.Arg422His	0.17714285
P13-Organoid	OR56A4	11	6023895	A	C	Missense_Mutation	ENST00000330728.4:c.484T>G	ENSP00000328215.4:p.Phe162Val	0.08823529
P13-Organoid	SYT9	11	7273496	C	A	Missense_Mutation	ENST00000318881.6:c.79C>A	ENSP00000324419.6:p.His27Asn	0.05633802
P13-Organoid	TRIM49	11	89531764	T	C	Missense_Mutation	ENST00000532501.2:c.662A>G	ENSP00000431618.2:p.Asn221Ser	0.13846153
P13-Organoid	CCDC15	11	124829861	G	C	Missense_Mutation	ENST00000529051.1:c.478G>C	ENSP00000435403.1:p.Glu160Gln	0.2
P13-Organoid	A2ML1	12	9006726	C	T	Missense_Mutation	ENST00000539547.1:c.1120C>T	ENSP00000438292.1:p.His374Tyr	0.11111111
P13-Organoid	KRAS	12	25398284	C	A	Missense_Mutation	ENST00000557334.1:c.35G>T	ENSP00000452512.1:p.Gly12Val	0.08823529
P13-Organoid	ATXN2	12	111895054	T	A	Missense_Mutation	ENST00000608853.1:c.3000A>T	ENSP00000476504.1:p.Gln1000His	0.08730158
P13-Organoid	UCHL3	13	76169062	A	G	Missense_Mutation	ENST00000377595.3:c.486A>G	ENSP00000366819.3:p.Ile162Met	0.16279069
P13-Organoid	ZFYVE26	14	68219074	C	T	Missense_Mutation	ENST00000557306.1:c.896G>A	ENSP00000452142.1:p.Arg299Lys	0.09523809
P13-Organoid	PLD4	14	105397232	C	T	Missense_Mutation	ENST00000540372.1:c.892C>T	ENSP00000438677.1:p.Pro298Ser	0.09848484
P13-Organoid	OR4M2	15	22369288	C	T	Missense_Mutation	ENST00000332663.2:c.713C>T	ENSP00000329467.2:p.Ala238Val	0.05974842
P13-Organoid	HERC1	15	64039262	T	C	Missense_Mutation	ENST00000443617.2:c.2375A>G	ENSP00000390158.2:p.Lys792Arg	0.05882352
P13-Organoid	GOLGA6B	15	72953677	G	A	Missense_Mutation	ENST00000421285.3:c.637G>A	ENSP00000408132.3:p.Ala213Thr	0.05982906
P13-Organoid	SLC5A2	16	31499407	G	C	Missense_Mutation	ENST00000330498.3:c.934G>C	ENSP00000327943.3:p.Ala312Pro	0.22772277
P13-Organoid	RILP	17	1552257	CGCGCA	C	Frame_Shift_Del	ENST00000301336.6:c.506_510del	ENSP00000301336.6:p.Leu169ArgfsTer21	0.125
P13-Organoid	TP53	17	7578416	C	A	Missense_Mutation	ENST00000455263.2:c.514G>T	ENSP00000398846.2:p.Val172Phe	0.13402061
P13-Organoid	PIGL	17	16120664	C	T	Missense_Mutation	ENST00000581006.1:c.124C>T	ENSP00000462432.1:p.Arg42Trp	0.06666666
P13-Organoid	CAPNS1	19	36632024	GGGCGGCGGC	G	In_Frame_Del	ENST00000590874.1:c.135_143del	ENSP00000465575.1:p.Gly54_Gly56del	0.44680851
P13-Organoid	SPRED3	19	38882694	C	G	Missense_Mutation	ENST00000587013.1:c.418C>G	ENSP00000467540.1:p.Pro140Ala	0.07608695
P13-Organoid	CEACAM16	19	45206709	G	A	Missense_Mutation	ENST00000587331.1:c.128G>A	ENSP00000466561.1:p.Gly43Glu	0.10869565
P13-Organoid	CNBD2	20	34571918	G	A	Missense_Mutation	ENST00000538900.1:c.422G>A	ENSP00000442729.1:p.Arg141His	0.11111111
P13-Organoid	TSHZ2	20	51872044	G	A	Missense_Mutation	ENST00000603338.2:c.2038G>A	ENSP00000475114.1:p.Ala680Thr	0.15827338
P13-Organoid	NPEPL1	20	57273798	G	A	Missense_Mutation	ENST00000525967.1:c.482G>A	ENSP00000434810.1:p.Cys161Tyr	0.11711711
P13-Organoid	UBASH3A	21	43833214	G	A	Missense_Mutation	ENST00000398367.1:c.436G>A	ENSP00000381408.1:p.Val146Met	0.14814814
P13-Organoid	CELSR1	22	46807575	T	C	Missense_Mutation	ENST00000262738.3:c.4693A>G	ENSP00000262738.3:p.Thr1565Ala	0.09836065
P13-Organoid	SLC9A7	X	46541775	C	T	Missense_Mutation	ENST00000328306.4:c.521G>A	ENSP00000330320.4:p.Arg174Gln	0.04347826
P13-Organoid	CPXCR1	X	88009029	A	G	Missense_Mutation	ENST00000373111.1:c.614A>G	ENSP00000362203.1:p.Tyr205Cys	0.12
P13-Organoid	FAM133A	X	92964950	A	C	Missense_Mutation	ENST00000538690.1:c.532A>C	ENSP00000441389.1:p.Lys178Gln	0.15476190
P13-Organoid	F8	X	154158530	C	G	Missense_Mutation	ENST00000360256.4:c.3535G>C	ENSP00000353393.4:p.Asp1179His	0.11494252
P13-Organoid	SPRY3	X	155003574	C	G	Missense_Mutation	ENST00000302805.2:c.41C>G	ENSP00000302978.2:p.Pro14Arg	0.1171875

Somatic Copy Number Alterations

Primary Tumor

Organoid

Concordance between Primary tumor and Organoid

VAF-VAF Plot

Number of Shared Mutations between Primary tumor and organoid (All mutations)

Number of Shared Mutations between Primary tumor and organoid (Functional mutations)

Drug Responses

ID	Drug	IC50
P13	AZD2014	~ 4.545e+016
P13	AZD3759	~ 5.563e-017
P13	AZD4547	~ 217267
P13	AZD5363	2377
P13	AZD6738	704.4
P13	AZD9291	100.5
P13	I.BET.762	845.6
P13	Rapamycin..Sirolimus.	~ 22609
P13	AZD1775..MK.1775.	20.36
P13	Triptolide..PG490.	33.23
P13	Simvastatin	~ 690103800983
P13	Temozolomide	~ 390.9
P13	Imatinib.Mesylate..STI571.	~ 4949
P13	Pazopanib..GW786034.	~ 766965299647
P13	Sunitinib.Malate	7131
P13	Olaparib..AZD2281..KU0059436.	144.1
P13	Regorafenib..BAY.73.4506.	~ 5223
P13	Erlotinib	~ 294.3
P13	Gefitinib	136.6
P13	Afatinib	306.9
P13	OTX.015	113.2
P13	BKM120..NVP.BKM120.	1875
P13	BYL719	5688
P13	Cediranib..AZD2171.	6346
P13	Ceritinib.LDK378.	1114
P13	Crizotinib...PF.02341066.	~ 4717483595
P13	Dabrafenib	~ 19.13
P13	Dacomitinib	~ 5.503e+021
P13	Everolimus..RAD001.	~
P13	Ibrutinib..PCI.32765.	~ 1.890e+026
P13	Lapatinib	~ 13901955607667
P13	LY2835219	1674
P13	Brivanib..BMS.582664.	~ 1384
P13	Panobinostat	122.2
P13	Selumetinib..AZD6244.	739
P13	Sorafenib	~ 6928
P13	Trametinib	26.35
P13	Vandetanib..ZD6474.	1117
P13	Vemurafenib	~ 17769
P13	AZD5153	551.1
P13	ABT.199..GDC.0199..	~ 2049012
P13	ABT.888..Veliparib..NSC.737664.	~ 22286681
P13	Avagacestat..BMS.708163.	3598
P13	Axitinib...AG.013736.	2598
P13	Bosutinib..SKI.606.	660.6
P13	Cabozantinib..XL184.	21662
P13	Dasatinib..BMS.354825.	~ 1.901e+029
P13	decitabine	~ 2166
P13	defactinib	~ 4257829687161
P13	Dovitinib..TKI258.CHIR258.	2674
P13	Fluorouracil..5.Fluoracil..5.FU.	~ 2.419e+017
P13	Foretinib..XL880.	1054
P13	Tivantinib..ARQ.197.	7981
P13	Abraxane	~ 1.468
P13	AZD2461.olaparib.analog.	~ 1194
P13	Olaparib.	~ 8.874e-102
P13	Idelalisib	1809
P13	Irinotecan	832
P13	Nilotinib..AMN.107.	14698
P13	NVP.AEW541	~ 9.510e+017
P13	Oxaliplatin	~ 11823
P13	PLX3397	21807
P13	Quizartinib..AC220.	16310
P13	Saracatinib..AZD0530.	1319
P13	Semagacestat..LY450139.	1185
P13	TGX.221	~ 20764
P13	tozasertib	~ 1.240e+018
P13	Vorinostat..SAHA..MK0683.	~ 4.099e+016
P13	XAV939	~ 5650
P13	gemcitabine	~
P13	palbociclib	~ 1.374e-014
P13	Neratinib..HKI.272.	~ 6.820e-036