DISCONTINUE

Please contact Prof. Semin Lee, Seunghoon Kim or Web-master for any inquires.

Patient Information

IndexColumn	Subject number	UPN	Dx date	Diagnosis BM Cell	RNA Amount (ug)	Transcript type	1st TKI	1st TKI start date	1st TKI stop date	2nd TKI	2nd TKI start date	2nd TKI stop date	3rd TKI	3rd TKI start date	3rd TKI stop date	Disconti date (C1D1)	TKI Tx duration	last F/U date	F/U duration (mos)	loss of UMRD(1st positive)	Time from Enrollment to UMRD loss (Cycle)	IS % Relapse	Relapse date	Time from Enrollment to MMR loss (Cycle)	Time from Enrollment to MMR loss (mos)	Relapse BM date	RE-TKI start date	Comment	Sokal score	Hasford score	EUTOS	ELTS	Timepoint	Date	WBC	ANC	Hemoglobin	Hematocrit	Platelet	Seg. Neutrophil	Band Neutrophil	Lymphocytes	Monocytes	Eosinophils	Basophils	Metamyelocyte	Myelocytes	Promyelocyte	Blasts	Others	scRNAseq	scRNAseq Sample name	서비스 (5'GEX)	서비스 (TCR)	서비스 (BCR)	CD33	MTRNR2L12	CD74	HIST1H1D	ALDOA	IL7R	EFHD2	GNAI2	TNF	BRD2	VIM	IFITM1	IFITM3	CD81	AHNAK	ETS1	SRRM2	ZFP36
O-Mrel-Y	DIS-010	KRCMC01193	16-Aug-11	Y	233.11	e14a2	Radotinib	30-Aug-11	13-Oct-20	N	N	N	N	N	N	14-Oct-20	111.1	4-Aug-22	22.0	5-Jan-21	C3D28	0.11694	2-Feb-21	C4D28	3.7	4-Mar-21	5-Mar-21		H	H	L	L	Dx	16-Aug-11	187.97	118.42	9.1		1156	63	0	2	3	12	5	4	7	0	4	0	1	DIS-010-D	Y	Y		34.36981316	1368.838744	1661.144859	113.0503418	130.986079	313.0702228	684.8598725	400.7295111	416.8573928	473.4447687	1266.241498	2089.164146	266.7328368	402.1347282	641.5455806	506.3648916	617.4944226	2223.138805
																																	Scr	13-Oct-20	3.58	1.93	11.5	34.1	153	54	0	36	9	1	0	0	0	0	0	0	1	DIS-010-S	Y	Y		41.71829347	1090.218679	1346.997474	105.4522721	201.0174276	399.5477167	469.631938	335.561148	335.1064012	618.1101316	1051.712874	2359.948726	308.3386272	334.3166723	472.5156747	476.2038038	593.1475843	1685.618487
																																	Relapse	4-Mar-21	3.53	1.59	11.8	35.6	161	45	0	47	6	2	0	0	0	0	0	0	1	DIS-010-R	Y	Y		53.01277601	3685.119544	1144.280489	128.898737	179.5209107	357.0744431	486.0514178	292.5075267	850.3750149	529.3494575	931.759915	1714.629293	233.3214751	273.9643912	493.3812697	552.2878344	729.840101	2847.552223
O-Mrel-Y	DIS-025	KRCMC01572	30-May-14	Y	97.094	e13a2	Dasatinib	19-Jun-14	26-Oct-20	N	N	N	N	N	N	27-Oct-20	77.4	5-Aug-21	9.4	17-Dec-20	C2D28	0.52023	14-Jan-21	C3D28	2.6	18-Feb-21	19-Feb-21	EOS	I	L	H	L	Dx	30-May-14	23.57	13.91	15.1		1338	59	0	17	3	4	15	0	2	0	0	0	1	DIS-025-D	Y	Y	Y	49.23781102	1916.721521	718.0681109	106.0930424	162.7391839	595.8929125	280.3020344	300.3519233	112.7332502	577.2309936	1080.736197	1651.307264	218.7927877	232.3357912	549.1355651	610.9705604	592.1248457	1650.679317
																																	Scr	26-Oct-20	5.02	2.26	14	41.7	231	45	0	49	5	1	0	0	0	0	0	0	1	DIS-025-S	Y	Y	Y	59.21842764	2509.105825	1100.821378	86.60175536	210.6650975	342.7672342	731.6656512	421.3052179	223.656935	610.1977268	857.0661	1628.290926	222.9541361	445.9470221	1184.613559	615.3981355	690.6661583	2277.728103
																																	Relapse	18-Feb-21	4.94	3.56	13.2	39.9	263	72	0	20	7	1	0	0	0	0	0	0	1	DIS-025-R	Y	Y	Y	70.231488	1767.121406	1274.547678	71.30425807	200.1455785	551.3734485	516.5192857	353.6333645	191.1717154	461.952163	1025.420759	1553.53182	256.3901124	408.9810469	1025.322328	621.8682016	602.2445287	2217.301535
O-Mrel-Y	DIS-030	KRCMC01237	29-Nov-11	Y	46.01	e14a2	Radotinib	16-Dec-11	3-Dec-12	Imatinib	18-Dec-12	3-Nov-20	Imatinib	18-Dec-12	3-Nov-20	4-Nov-20	108.2	4-Aug-22	21.3	5-Jan-21	C2D28	0.2363	26-Jan-21	C3D28	2.8	23-Feb-21	24-Feb-21		I	I	H	H	Dx	29-Nov-11	113.63	78.4	8.5		174	69	0	6	1	5	11	2	6	0	0	0	1	DIS-030-D	Y	Y	Y	46.4279667	4986.036428	902.2185058	162.3210301	140.4324493	522.1499204	455.1747143	303.6658288	46.35152318	231.0367974	848.7744291	1592.109889	212.2187081	240.9078804	817.9441598	628.1947829	853.1822116	385.2116146
																																	Scr	3-Nov-20	4.1	2.46	14	40.7	166	60	0	27	8	5	0	0	0	0	0	0	1	DIS-030-S	Y	Y	Y	45.54630524	2246.949179	1137.05637	114.8024167	145.2229167	398.2712488	465.2031553	395.2772657	121.0871516	445.7901432	1118.892072	1475.042865	213.8838917	373.855859	871.5639562	535.9674331	702.1833156	1795.894062
																																	Relapse	23-Feb-21	6.68	3.87	15.1	45.2	208	58	0	32	7	2	1	0	0	0	0	0	1	DIS-030-R	Y	Y	Y	62.98117986	4239.163447	1053.394113	99.05278824	113.0567327	407.0320334	516.7431301	330.1634704	87.41308322	386.0605168	874.7468655	1272.530605	171.893305	314.7574106	992.4896209	557.5880335	814.5636504	644.8660469
O-Mrel-Y	DIS-035	KRCMC01093	6-Dec-10	Y	82.49	e14a2	Imatinib	15-Dec-10	14-Apr-11	Radotinib	3-Jun-11	6-Nov-20	N	N	N	7-Nov-20	120.5	4-Aug-22	21.2	04-Feb-21	C3D28	0.12309	25-Feb-21	C4D28	3.7	30-Mar-21	31-Mar-21		L	L	L	L	Dx	6-Dec-10	94.29	64.12	10.8		314	62	6	5	4	4	4	9	5	0	1	0	1	DIS-035-D	Y	Y		39.81881393	21387.41239	915.9823754	310.8943287	153.0274046	590.037171	355.3331717	186.455721	272.6726385	494.8352094	610.4741969	1213.76194	136.8419793	162.2961727	708.473193	1050.534663	1176.064686	1864.610502
																																	Scr	6-Nov-20	9.35	6.17	8.6	30	281	66	0	28	4	2	0	0	0	0	0	0	1	DIS-035-S	Y	Y		50.77485884	6406.382999	1738.687626	176.6586801	310.1626013	934.7563717	353.0146026	339.4944347	135.7802034	365.6310117	1130.36815	2170.651089	244.1044241	418.7532858	1015.266619	1099.037242	799.1779522	1344.536292
																																	Relapse	30-Mar-21	6.84	4.24	9.2	30.2	292	62	0	29	7	2	0	0	0	0	0	0	1	DIS-035-R	Y	Y		40.40385425	3754.182869	1718.963204	118.5018974	252.721457	516.2284282	460.6420249	392.2794528	213.4657769	562.1178757	1146.643189	2210.720077	287.146516	385.4380269	808.4199212	666.3128296	820.9491471	2341.085586
O-Mrel-Y	DIS-043	KRCMC00968	12-May-10	Y	107.18	e13a2	Imatinib	18-May-10	16-Nov-20	N	N	N	N	N	N	17-Nov-20	127.9	2-Jul-21	7.6	5-Feb-21	C3D28	0.20756	5-Feb-21	C3D28	2.7	5-Mar-21	6-Mar-21	f/u loss	L	L	L	L	Dx	12-May-10	82.1	46.8	14		284	47	10	9	2	2	2	12	12	2	1	1	1	DIS-043-D	Y	Y		61.08870275	2014.28671	1403.717512	253.1646097	206.5924596	538.5591256	743.3151344	483.5287139	144.5371076	417.6086106	1176.812103	1831.652647	273.4837174	484.8283832	901.1707242	744.7226038	568.8946765	2462.271219
																																	Scr	16-Nov-20	5.65	3.16	14.9	45.5	276	56	0	33	9	2	0	0	0	0	0	0	1	DIS-043-S	Y	Y		56.26880525	1315.465104	1270.718155	78.1864926	249.0632369	470.0791153	580.6286398	406.9860404	229.7018702	696.5136154	1271.231724	1445.630274	257.2904598	437.7412411	902.6922985	479.3461717	584.9333968	2163.153557
																																	Relapse	5-Mar-21	7.86	3.62	15.3	46.2	285	46	0	35	15	4	0	0	0	0	0	0	1	DIS-043-R	Y	Y		64.5112863	1486.832925	1212.963765	105.8277882	215.587028	883.8275672	534.2751804	422.9059327	183.184013	323.1585347	1653.321074	1538.381399	281.7040284	411.6052849	978.6117545	592.0849217	479.9779199	2135.420191
O-Mrel-Y	DIS-048	KRCMC01015	8-Jul-10	Y	116.45	e14a2	Imatinib	16-Jul-10	19-Nov-20	N	N	N	N	N	N	20-Nov-20	126.0	4-Aug-22	20.7	9-Feb-21	C3D28	0.10158	11-Mar-21	C4D28	3.7	2-Apr-21	3-Apr-21		I	L	L	L	Dx	8-Jul-10	93.18	71.75	9.9		1249	69	8	2	1	2	3	6	8	1	0	0	1	DIS-048-D	Y	Y		49.28746661	2222.328389	979.3293202	167.2042872	159.8319884	329.5459516	712.8971539	409.1525256	528.7628107	417.0147516	1535.910978	2232.798274	405.6575918	408.9026251	1224.709356	497.9831177	809.3882688	1742.985525
																																	Scr	19-Nov-20	5.84	4.96	10.5	30.7	201	85	0	11	2	2	0	0	0	0	0	0	1	DIS-048-S	Y	Y		37.30185127	29514.1166	1734.623022	342.0329977	197.3272122	264.6150092	216.3064561	499.4252198	162.9364514	684.5214548	2319.906533	522.1081239	113.3038162	97.35690445	2000.048496	380.7526318	1345.116799	1777.418456
																																	Relapse	2-Apr-21	4.9	3.38	13.3	40	250	69	0	21	7	2	1	0	0	0	0	0	1	DIS-048-R	Y	Y		59.79070462	27864.87695	2417.452787	203.6681181	143.5061975	505.6180462	459.4440459	144.7322795	172.0637335	588.4891114	1948.118538	763.5681722	33.36907427	100.5828782	1364.181877	720.4746835	1041.143136	1337.492797
O-Mrel-Y	DIS-057	KRCMC01349	28-Sep-12	Y	16.17	e14a2	Imatinib	12-Oct-12	26-Nov-20	N	N	N	N	N	N	27-Nov-20	98.9	4-Aug-22	20.5	18-Feb-21	C3D28	0.11988	20-Aug-21	C10D28	8.9	14-Sep-21	15-Sep-21		L	L	L	L	Dx	28-Sep-12	32.47	19.81	13.4		487	61	0	16	4	4	2	2	11	0	0	0	1	DIS-057-D	Y	Y		0	25389.95329	503.7295481	135.9580865	176.1069645	610.9130268	480.9108315	282.1817929	186.9170282	537.3782507	545.2129164	1189.967506	142.7544682	192.8904051	1179.170245	1062.435649	1115.163608	821.3475866
																																	Scr	26-Nov-20	7.81	3.75	12.2	36	303	48	0	44	7	1	0	0	0	0	0	0	1	DIS-057-S	Y	Y		58.90958362	2163.299388	937.8460813	211.0496238	272.850651	639.8291609	392.3631199	341.7456817	98.6354262	370.9327201	985.647529	1859.692374	265.5811771	366.8363977	703.9566936	868.3859197	645.3257743	1358.080598
																																	Relapse	14-Sep-21	9.8	6.27	12.9	39.4	300	64	0	29	5	1	1	0	0	0	0	0	1	DIS-057-R	Y	Y		65.6691845	3302.101877	923.6080663	181.0331081	275.6102246	685.4253961	445.2884745	359.9541358	91.88319837	331.5452289	988.4913097	1787.236063	236.5540552	366.4932754	849.0252295	934.8659316	706.9663428	1129.032031
O-Mrel-Y	DIS-080	KRCMC00972	17-May-10	Y	126.88	e14a2	Imatinib	25-May-10	19-Feb-21	N	N	N	N	N	N	20-Feb-21	130.8	4-Aug-22	17.7	16-Apr-21	C2D28	0.23525	16-Apr-21	C2D28	1.8	11-May-21	12-May-21		L	L	L	L	Dx	17-May-10	121.61	100.94	11.4		485	73	10	3	0	1	5	5	3	0	0	0	1	DIS-080-D	Y	Y	Y	49.03387816	4365.163452	1199.05421	176.4517362	188.1100397	510.4912955	500.7009106	406.7924224	93.42869993	314.8474969	1146.525096	2018.461106	148.5970648	307.121967	756.3219135	670.7197844	572.0230627	1537.173387
																																	Scr	19-Feb-21	4	1.56	11.8	33.3	216	39	0	47	8	6	0	0	0	0	0	0	1	DIS-080-S	Y	Y	Y	60.78261305	2302.605124	1188.700668	115.2425038	143.3576574	476.3354282	511.3241605	393.0883119	196.187732	302.3107325	1309.583605	1578.725714	236.2389512	380.0908444	705.2360346	451.604522	531.0047094	1638.725275
																																	Relapse	11-May-21	6.62	3.64	14.7	43.1	307	55	0	36	6	3	0	0	0	0	0	0	1	DIS-080-R	Y	Y	Y	56.06641059	3052.640474	1235.337142	96.88377171	167.2518042	363.2534529	779.9344744	465.0835465	162.7355077	296.1015308	1330.322676	1923.67919	292.040176	436.5533253	997.5547856	518.8099312	540.6555702	1592.797597
X-Mrel-Y	DIS-012	KRCMC01140	11-Mar-11	N	N	e14a2	Imatinib	22-Mar-11	13-Oct-20	N	N	N	N	N	N	14-Oct-20	116.5	22-Jun-21	8.4	10-Nov-20	C1D28	0.70662	5-Jan-21	C3D28	2.8	02-Feb-21	3-Feb-21	EOS	H	I	H	L																			2 ScrX
X-Mrel-Y	DIS-013	KRCMC01492	19-Jul-13	N	N	e14a2	Nilotinib	1-Aug-13	16-Oct-20	N	N	N	N	N	N	17-Oct-20	87.8	4-Aug-22	21.9	10-Dec-20	C2D28	0.28858	5-Feb-21	C4D28	3.7	5-Mar-21	6-Mar-21		L	L	L	L	Scr																		2	DIS-013-S
																																	Relapse																		2	DIS-013-R
X-Mrel-Y	DIS-040	KRCMC01328	24-Jul-12	N	N	e14a2	Imatinib	24-Aug-12	27-Dec-12	Radotinib	28-Dec-12	12-Nov-20	N	N	N	13-Nov-20	100.1	4-Aug-22	21.0	4-Feb-21	C3D28	0.11847	5-Apr-21	C5D28	4.8	29-Apr-21	30-Apr-21		H	I	H	I	Scr																		2	DIS-040-S
																																	Relapse																		2	DIS-040-R
X-Mrel-Y	DIS-058	KRCMC00989	20-Mar-06	N	N	e14a2	Imatinib	22-Mar-06	27-Nov-20	N	N	N	N	N	N	28-Nov-20	178.8	23-Jul-21	7.9	22-Jan-21	C2D28	0.10469	26-Feb-21	C3D28	3.0	1-Apr-21	2-Apr-21	EOS	none	none	none	L	Scr																		2	DIS-058-S
																																	Relapse																		2	DIS-058-R
X-Mrel-Y	DIS-072	KRCMC01517	21-Jan-14	N	N	e14a2	Imatinib	30-Jan-14	22-Dec-20	N	N	N	N	N	N	23-Dec-20	84.0	4-Aug-22	19.6	16-Feb-21	C2D28	0.21434	13-Apr-21	C4D28	3.7	27-Apr-21	28-Apr-21		L	L	L	L	Scr																		2	DIS-072-S
																																	Relapse																		2	DIS-072-R
X-Mrel-Y	DIS-079	KRCMC00894	20-Oct-09	N	N	e14a2	Imatinib	21-Oct-09	1-Feb-21	N	N	N	N	N	N	2-Feb-21	137.4	4-Aug-22	18.3	29-Mar-21	C2D28	0.42604	26-Apr-21	C3D28	2.8	18-May-21	19-May-21		L	L	L	L	Scr																		2	DIS-079-S
																																	Relapse																		2	DIS-079-R
X-Mrel-Y	DIS-082	KRCMC01047	11-Jun-07	N	N	e14a2	Imatinib	28-Jun-07	25-Feb-21	N	N	N	N	N	N	26-Feb-21	166.4	4-Aug-22	17.5	26-Apr-21	C2D28	0.43817	21-May-21	C3D28	2.8	11-Jun-21	12-Jun-21		none	none	none	L	Scr																		2	DIS-082-S
																																	Relapse																		2	DIS-082-R
X-Mrel-Y	DIS-085	KRCMC01669	31-May-13	N	N	e14a2	Dasatinib	21-Jun-13	09-Mar-21	N	N	N	N	N	N	10-Mar-21	94.0	20-Aug-21	5.4	27-Jul-21	C5D28	0.22617	20-Aug-21	C6D28	5.4	ND	21-Aug-21	C6D28(20-Aug-21)방문시 EOS하여 BM검체없음.	I	I	L	L																			2 RelapseX
X-Mrel-Y	DIS-088	KRCMC01404	8-Mar-13	N	N	e14a2	Imatinib	5-Apr-13	24-Aug-13	비재발군	6-Sep-13	19-May-18	Radotinib	3-Jun-15	6-Apr-21	7-Apr-21	97.5	27-Jul-21	3.7	1-Jun-21	C2D28	0.10008	27-Jul-21	C4D28	3.7	ND	28-Jul-21	Withdrawal Syndrome(Arthralgia-Hip joint G3, Both shoulder G3)으로 인하여 EOS하여 BM검체없음.	I	I	L	I																			2 RelapseX
X-Mrel-Y	DIS-100	KRCMC01944	14-Mar-16	N	N	e13a2	Dasatinib	14-Mar-16	28-Feb-17	Imatinib	29-Mar-17	03-Jun-21	N	N	N	04-Jun-21	63.6	4-Aug-22	14.2	26-Jul-21	C2D28	0.12091	24-Sep-21	C4D28	3.7	20-Aug-21(3M)	20-Oct-21	C3에 BM검체 수집하여 재발시점에 추가검체를 수집하지 않음.	H	H	L	L	Scr																		2	DIS-100-S
																																	Relapse																		2	DIS-100-R
X-Mrel-Y	DIS-027	KRCMC00496	23-Aug-02	N	N	e14a2	Imatinib	23-Apr-03	30-Oct-20	N	N	N	N	N	N	31-Oct-20	213.4	4-Aug-22	21.4	30-Oct-20	0	0.13423	17-Mar-22	C18D28	16.7	8-Apr-22	9-Apr-22	Screening RQ-PCR: 0.01655(30-OCT-2020)	none	none	none	none	Scr																		2	DIS-027-S
																																	Relapse																		2	DIS-027-R
X-Mrel-Y	DIS-059	KRCMC01707	5-Feb-15	N	N	e14a2	Dasatinib	10-Feb-15	01-Dec-20	N	N	N	N	N	N	02-Dec-20	70.7	4-Aug-22	20.3	15-Jul-21	C8D28	0.1104	20-May-22	C19D28	17.8	13-Jun-22	14-Jun-22		H	I	H	L	Scr																		2	DIS-059-S
																																	Relapse																		2	DIS-059-R
X-Mrel-Y	DIS-019	KRCMC01880	28-Feb-11	N	N	e13a2	Imatinib	11-Mar-11	3-Jun-12	Nilotinib	11-Jun-12	21-Apr-13	Dasatinib	29-Dec-14	8-Nov-15	21-Oct-20	117.1	4-Aug-22	21.7	15-Dec-20	C2D28	0.112	31-May-22	C21D28	19.6	20-Jun-22	21-Jun-22		I	I	L	L	Scr																		2	DIS-019-S
																																	Relapse																		2	DIS-019-R